Prevalence of Hyponatremia in Dengue Infected Patients: Relationship With Systemic Inflammation.

Recruiting

• Conditions: Inflammation; Hyponatremia; Dengue

• Registration Number: NCT06109532
• Lead Sponsor: Hospital Nacional Profesor Alejandro Posadas

Brief Summary

Prospective cohort study in patients with newly diagnosed dengue infection at Hospital Posadas in Argentina, between January 1, 2016, and November 1, 2023. Diagnosis was confirmed by IgM serology or PCR. Hyponatremia was defined as serum sodium concentration ≤135 mEq/L.

Detailed Description

Background Dengue infection is becoming more prevalent worldwide and is associated with systemic inflammation. Systemic Inflammation is associated with non-osmotic release of ADH.

Methods: Participants conducted a prospective cohort study in patients with newly diagnosed dengue infection at Hospital Posadas in Argentina, between January 1, 2016, and November 1, 2023. Diagnosis was confirmed by IgM serology or PCR. Hyponatremia was defined as serum sodium concentration ≤135 mEq/L.

Study Timeline

• Study Start: 2016-01-01
• Status Verified: 2023-10
• Study First Submitted: 2023-10-25
• Study First Submitted QC: 2023-10-25
• Primary Completion: 2023-10-30
• Study Completion: 2023-10-31
• Study First Posted: 2023-10-31
• Last Update Submitted: 2023-10-31
• Last Update Posted: 2023-11-02

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 530

Inclusion Criteria

• Diagnosis confirmed by PCR, non structural protein 1 (NS1) antigen or IgM serology.

Plasma sodium at admission.

Exclusion Criteria

• None

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Admission to the hospital	between january 1, 2023 and november 1, 2023	Risk for admission to the hospital

Trial Locations

Locations (2)

Ladislao Diaz Ballve; 🇦🇷 Haedo, Buenos Aires, Argentina

Hospital Posadas; 🇦🇷 Buenos Aires, Argentina