Effect of Protein-Restricted Diet on Nitrogen Balance and Residual Renal Function in Peritoneal Dialysis (PD) Patients
- Conditions
- Chronic Kidney DiseasePeritoneal Dialysis
- Interventions
- Dietary Supplement: diets contained different levels of protein
- Registration Number
- NCT00633646
- Lead Sponsor
- Shanghai Jiao Tong University School of Medicine
- Brief Summary
Current therapy recommendations suggest a low protein diet to preserve residual renal function (RRF) before the start of dialysis, but a higher protein intake during dialysis to prevent protein-energy wasting (PEW). We conducted a randomized trial to test whether low protein intake also during treatment with peritoneal dialysis (PD) would be safe and associated with a preserved RRF.
- Detailed Description
Dietary protein is the major source of nitrogen excreted as urea by the kidney, and a decreased protein intake has been associated with a retardation of kidney function loss in non-dialysis chronic kidney disease (CKD) patients. While a low protein diet is recommended to end-stage renal disease (ESRD) patients before the start of dialysis to preserve residual renal function(RRF), current therapy recommendations in dialysis are for a normal protein intake of no less than 1.2 g of protein/kg ideal body weight (IBW)/day to prevent protein-energy wasting (PEW).
We hypothesized that a lower protein intake would be safe and able to slow the loss of RRF also in dialysis patients and conducted two prospective, randomized trials involving a total of 94 peritoneal dialysis (PD) patients to test our hypothesis.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 94
- age 18-80 years
- stable peritoneal dialysis since at least 1 month
- with renal function
- a high probability (assessed by the recruiting physician) of receiving a kidney transplant within one year
- overt infection within the last month
- poor compliance in previous dietary prescriptions or irregular check-ups
- persistent anorexia, vomiting or diarrhea within the last month
- a CRP of more than 30 mg/dL
- presence of wasting diseases such as cancer or tuberculosis
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1 diets contained different levels of protein low protein diet 2 diets contained different levels of protein low protein diet with keto acids 3 diets contained different levels of protein high protein diet
- Primary Outcome Measures
Name Time Method nitrogen balance,residual renal function and nutritional status 10 day and 1 year
- Secondary Outcome Measures
Name Time Method