MicroRNAs in Acute Kidney Injury

Completed

• Conditions: Kidney Injury in Cardiac Surgery - Expression of microRNAs

• Registration Number: NCT03089242
• Lead Sponsor: Heinrich-Heine University, Duesseldorf

Brief Summary

Profiling of microRNAs and long noncoding RNAs (lncRNAs) in patients undergoing cardiac surgery. Analysis: Prediction of acute kidney injury by plasma expression profile of microRNAs?

Detailed Description

In this pilot study we will include 150 patients undergoing cardiac surgery in a German university hospital. We will profile microRNA expression in plasma and urine before and at several timepoints after surgery. We will use a preselected panel of microRNAs and lncRNAs for analysis. Goal is to identify microRNAs/lncRNAs that are able to predict the occurence of AKI in these patients.

Study Timeline

• Study First Submitted: 2017-03-20
• Study First Submitted QC: 2017-03-20
• Study First Posted: 2017-03-24
• Study Start: 2017-09-01
• Primary Completion: 2018-06-30
• Study Completion: 2018-12-31
• Status Verified: 2020-05
• Last Update Submitted: 2020-05-06
• Last Update Posted: 2020-05-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• cardiac surgery

Exclusion Criteria

• preexisting chronic kidney injury
• inclusion in another study
• pregnancy
• Kidney transplantation in history
• GFR < 30 ml/min (glomerular filtration rate)
• ECLS therapy (extracorporal life support)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
acute kidney injury	1 year	AKI Stadium II or III following cardiac surgery.

Trial Locations

Locations (1)

Klinik für Anästhesiologie; 🇩🇪 Düsseldorf, Germany