Precision Radiation treatment for Epilepsy - PRECISIO

MAASTRO clinic0 个研究点目标入组 94 人开始时间: 待定最近更新: 2024年4月9日

适应症

试验速览

暂无简介。

•1. Age >= 18 years, non-pregnant, written informed consent
•2. The patient or caretaker is able to keep an epilepsy diary
•3. The patient has a diagnosis of epilepsy established by a dedicated
•neurologist
•4. The patient had at least 3 focal-onset seizures with impairment of
•consciousness over a 3-month period despite two or more antiepileptic
•medication trials (according ILAE Task Force on therapeutic strategies)
•5. Video electroencephalography to determine a well-circumscribed seizure focus
•6. Imaging evidence (i.e. 3T-MRI) of the anatomic region to be targeted with
•SRT, correlating with the EZ hypothesis
•7. A Wada test or a functional MRI to lateralize language has been performed in
•selected patients
•8. The patient has completed a standard battery of neuropsychological testing
•9. The patient been deemed an appropriate candidate for stereotactic
•radiosurgery by a dedicated Radiation Oncologist and Neurosurgeon and referred
•for the study by one of the Dutch regional multidisciplinary epilepsy surgery
•working groups
•10. Patients that were rejected for surgery in an earlier stage can participate
•in the trial if the treatment with VNS/DBS was more than 4 years ago.

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