Antler Plate on Preventing Mammary High-risk Lesions From Malignant Development
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 6,000
- 试验地点
- 1
- 主要终点
- Canceration by biopsy
研究概览
简要总结
This study aims to prove whether antler disk extract can be put into clinical practice to prevent breast precancerous lesions from developing into cancer.
详细描述
Through estrogen receptor antagonists, tamoxifen can reduce the risk of breast high-risk disease progression to cancer, but only reduce the probability of some ER and PR positive tumors, which has no preventive effect on triple negative breast cancer and HER-2 positive breast cancer. In the first hospital of Jilin University, the preparations containing antler ingredients have been clinically proven to be able to treat breast hyperplasia, which has been proved to be able to prevent breast cancer in basic research, and antler ingredients have been proved to be non-toxic and side effects in the treatment dose. This study aims to prove whether antler disk extract can be put into clinical practice to prevent breast precancerous lesions from developing into cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women between the ages of 18 and 80
- •Atypical hyperplasia or / and lobular carcinoma in situ confirmed by breast histology
- •Women with breast cancer in first degree relatives
- •Patients have better compliance with a series of research-related behaviors such as the upcoming comprehensive treatment and follow-up, and can understand and accept the research process of this study, and sign a written informed consent
排除标准
- •Hepatorenal dysfunction, cardiovascular and cerebrovascular diseases
- •Patients not suitable for this study judged by researchers
结局指标
主要结局
Canceration by biopsy
时间窗: 1 year
Imaging suspected malignant, confirmed by pathology
次要结局
未报告次要终点
研究者
Aiping Shi
professor
Jilin University