Electrical Stimulation Combined With Motor Training on EEG-EMG Coherence and Motor Function in Individuals With Stroke

Not Applicable

Completed

• Conditions: Stroke
• Interventions: Other: Electrical stimulation; Other: Sham electrical stimulation

• Registration Number: NCT03277534
• Lead Sponsor: National Yang Ming Chiao Tung University

Brief Summary

This study investigated whether electrical stimulation (ES) prior to a hand function training session for a total of eight weeks can better improve neuromuscular control and hand function in subacute stroke individuals and change electroencephalography-electromyography (EEG-EMG) coherence, as compared to the control (sham ES).

Detailed Description

Subjects were randomly assigned into ES and control groups. Both groups received 20-minute hand function training twice a week, and the ES group received 40-minute ES on the median nerve of the affected side before each training session. The control group received sham ES - electrodes were placed on the same location but no electric current was applied. EEG, EMG and Fugl-Meyer Assessment (FMA) were collected before, at the 4th week, at the end of 8th week, and 4 weeks after the end of intervention.

Study Timeline

• Study Start: 2013-08-28
• Primary Completion: 2017-01-04
• Study Completion: 2017-01-04
• Status Verified: 2017-09
• Study First Submitted: 2017-09-05
• Study First Submitted QC: 2017-09-06
• Last Update Submitted: 2017-09-06
• Study First Posted: 2017-09-11
• Last Update Posted: 2017-09-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

1. first-ever cerebral cortical region involved chronic stroke, onset over a month,
2. able to perform active thumb flexion on the affected side with the scores of manual muscle test at least two points, and
3. at stable medical condition for intervention

Exclusion Criteria

1. history of other neurological disorders,
2. cognitive impairment (Mini-Mental State Examination score <24, MMSE),26
3. unable to follow orders,
4. contraindications of ES, and
5. under 20 years old

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Electrical stimulation	Electrical stimulation	-
Control	Sham electrical stimulation	-

Primary Outcome Measures

Name	Time	Method
Fugl-Meyer Assessment for Upper Extremity	before intervention, four weeks after, at the end of the eight-week intervention and four weeks after the intervention period ended	evaluate changes in upper extremity function of the stroke subjects
EEG-EMG coherence	before intervention, four weeks after, at the end of the eight-week intervention and four weeks after the intervention period ended	evaluate changes in functional connectivity between motor cortex and active muscles