A Comparative Study Of Selected Outcomes Of Treatment With Ursodeoxycolic Acid (UDCA) Vs UDCA+ Phototherapy In Patients With Intrahepatic Cholestasisof Pregnancy - Randomized Control Trial
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- additional benefit of Phototherapy in treatment of IHCP
研究概览
简要总结
Intrahepatic cholestasis of pregnancy is a reversible form of hormonally triggered cholestasis that typically develops in genetically predisposed individuals in late pregnancy. The aim of treatment is the reduction of serum bile acid levels in order to prolong pregnancy and reduce both fetal risks and maternal symptoms. Ursodeoxycholic acid (UDCA) not only reduces maternal pruritus but to also improves fetal prognosis.Both narrowband (NBUVB) and broadband (BBUVB) ultraviolet B light phototherapy are considered safe options in pregnancy. Phototherapy to the skin with ultraviolet (UV) light B is used by some clinicians to treat the pruritus of cholestasis. UVB has been variably helpful in IHCP.
My aim is to compare the selected outcomes of treatment with URSODEOXYCHOLIC ACID (UDCA) vs UDCA+PHOTOTHERAPY in patients with Intrahepatic Cholestasis of Pregnancy
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 45.00 Year(s)（—）
- 性别
- Female
入选标准
- •All ANC cases with IHCP.
排除标准
- •Women with pruritic skin diseases and other liver pathologies wh are already on treatment for IHCP Lethal fetal anomalies.
结局指标
主要结局
additional benefit of Phototherapy in treatment of IHCP
时间窗: at baseline and weekly till delivery
次要结局
- 5D Pruritus Scale for assessment of Pruritus(Lab Parameters)