Filling Key Research Gaps With Clinical Implications in Mansonellosis and Schistosomiasis: a Network Approach
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Schistosoma Mansoni
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Percentage of M. perstans microfilariae
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
This is an experimental, multicenter, non-profit study promoted by the Department of Infectious and Tropical Diseases of the IRCCS (Istituto di Ricerca e Cura a carattere scientifico) Sacro Cuore Don Calabria of Negrar which aims to evaluate the presence of endosymbiont Wolbachia in circulating microfilariae obtained from biological samples of individuals infected with M .perstans and the presence of infection with hybrid Schistosoma species in the population of Schistosoma eggs isolated from biological samples of patients with active schistosomiasis.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Percentage of M. perstans microfilariae
Time Frame: Baseline
Percentage of samples, defined as the whole M. perstans microfilariae retrieved from one blood sample from each patient, positive for the presence of Wolbachia as assessed by PCR.
Number of Schistosoma eggs
Time Frame: Baseline
Number of samples defined as the whole Schistosoma eggs retrieved from one stool or urine sample from each patient, positive for the presence Schistosoma hybrid species.
Percentage of Schistosoma eggs
Time Frame: Baseline
Percentage of samples defined as the whole Schistosoma eggs retrieved from one stool or urine sample from each patient, positive for the presence Schistosoma hybrid species.
Number of M. perstans microfilariae
Time Frame: Baseline
Number of samples, defined as the whole M. perstans microfilariae retrieved from one blood sample from each patient, positive for the presence of Wolbachia as assessed by PCR.
Secondary Outcomes
- Identification of hybrid species of Schistosoma spp.(Baseline)
- Percentage of samples positive for Wolbachia(Baseline)
- Number of samples positive for Wolbachia(Baseline)
- Number of samples positive for Schistosoma hybrid species(Baseline)
- Percentage of samples positive for Schistosoma hybrid species(Baseline)