Phase I/II Study of Allogeneic Stem Cell Transplantation For Patients With Graft Failure Following Allogeneic Transplantation Using MHC Identical or Near Identical Donors and Submyeloablative Conditioning With CAMPATH 1H (CAMGRAFT)
Trial Snapshot
- Phase
- Phase 1
- Status
- Terminated
- Sponsor
- Baylor College of Medicine
- Enrollment
- 40
- Locations
- 2
Study Overview
Brief Summary
To assess the safety, feasibility, and rate of donor engraftment for patients with primary or secondary engraftment failure after treatment with fludarabine and CAMPATH 1H used as a preparative regimen for HLA-identical sibling blood stem cell transplantation (SCT).
To assess the safety, feasibility, and rate of donor engraftment for patients with primary or secondary engraftment failure after treatment with fludarabine and CAMPATH 1H as a preparative regimen for matched unrelated or single antigen mismatched family donor marrow transplantation.
Detailed Description
Study participants will receive the following treatment:
Day -5 to -2...Fludarabine 30mg/m2* and CAMPATH** 1H 10mg IV
Day -1.........Day of rest
Day 0..........Stem cell transplant (infusion)
Where possible, patients will receive peripheral blood stem cells. When peripheral stem cells are unavailable (e.g. from some unrelated donor centers) or insufficient, bone marrow will be substituted. If peripheral blood stem cell collection is performed, the donor will be stimulated with G-CSF for 5 days and cells collected and frozen until the stem cell target number is obtained prior to the patient beginning the therapy. If a bone marrow harvest is performed, this will be performed on Day 0 (infusion day). After transplantation, G-CSF 5 micrograms/kg/day will be administered SC from day 7 until granulocytes >1000/ul.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- — to 64 Years (Child, Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Diagnosis of engraftment failure either primary or secondary, following allogeneic transplantation. Graft failure is defined as absolute neutrophil count < 500/mm3 and/or platelet count < 20,000/mm
- •Primary graft failure is defined as failure to maintain absolute neutrophil count > / = 500/mm3 for 3 consecutive days following allogeneic transplantation. Secondary graft failure is defined as failure to sustain an absolute neutrophil count > / = 500/mm3 after attainment of primary engraftment or failure to sustain platelet count > / = 20,000/mm3 despite neutrophil engraftment. For SCID patients, graft failure is defined as failure to recover > / = 500/mm3 T-cells and/or failure to generate satisfactory response to in vitro mitogen stimulation. For patients with genetic diseases, engraftment failure is defined as donor chimerism insufficient to correct or overcome the genetic or metabolic deficiency.
- •Available Healthy Donor without any contraindications for donation (5/6 or 6/6 related donor or 5/6 or 6/6 unrelated donor (molecular typing for DRB1)
- •Age between birth and 65
- •For women of childbearing potential, negative pregnancy test
Exclusion Criteria
- •Pregnant and lactating women or women unwilling to use contraception.
- •Uncontrolled intercurrent infection
- •Refractory AML or ALL
- •Untreated Blast Crisis for CML
- •Uncontrolled High-grade lymphoproliferative disease/lymphoma
- •Unstable angina and uncompensated congestive heart failure (Zubrod of 3 or greater)
- •Severe chronic pulmonary disease requiring oxygen (Zubrod of 3 or greater)
- •Hemodialysis dependent
- •Active Hepatitis or cirrhosis with total bilirubin, SGOT, or SGPT greater than 3 x normal.
- •Concurrent solid organ malignancy not in remission, except for Stage 0 or A prostate cancer.
- •Unstable Cerebral vascular disease and recent hemorrhagic stroke (less than 6 months)
- •Active CNS disease from hematological disorder.
Investigators
Robert Krance
Professor
Baylor College of Medicine