NL-OMON27990尚未招募不适用
Age-adjusted D-dimer cut-off levels to rule out pulmonary embolism: a prospective outcome study.
Academic Medical Center in collaboration with centers in The Netherlands, France, Switzerland and Belgium0 个研究点目标入组 2,400 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 2,400
研究概览
简要总结
- Douma RA, le Gal G, Söhne M, Righini M, Kamphuisen PW, Perrier A, Kruip MJHA, Bounameaux H, Büller HR, Roy PM. Age-adjusted D-dimer cut-off levels increase the ability to safely rule out pulmonary embolism in older patients: a retrospective analysis of three large management study cohorts. BMJ, in press
2. van Belle A, Büller HR, Huisman MV, Huisman PM, Kaasjager K, Kamphuisen PW, Kramer MH, Kruip MJ, Kwakkel-van Erp JM, Leebeek FW, Nijkeuter M, Prins MH, Sohne M, Tick LW. Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D-dimer testing, and computed tomography. JAMA 2006;295:172-9.
3. Djurabi RK, Klok FA, Nijkeuter M, Kaasjager K, Kamphuisen PW, Kramer MH, Kruip MJ, Leebeek FW, Büller HR, Huisman MV. Comparison of the clinical usefulness of two quantitative D-Dimer tests in patients with a low clinical probability of pulmonary embolism. Thromb Res 2009;123:771-4.
4. Huisman MV, Klok FA. Diagnostic management of clinically suspected acute pulmonary embolism. J Thromb Haemost 2009;7 Suppl 1:312-7.
5. Klok FA, Mos IC, Nijkeuter M, Righini M, Perrier A, Le Gal G, Huisman MV. Simplification of the revised Geneva score for assessing clinical probability of pulmonary embolism. Arch Intern Med 2008;168:2131-6.
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •All outpatients >50 years admitted to the emergency ward for suspected pulmonary embolism defined as acute onset of new or worsening shortness of breath or chest pain without another obvious etiology will be included in the study, provided they have signed an informed consent form.
排除标准
- •1. PE suspicion raised more than 24 hours after admission to the hospital;
- •2. Absence of informed consent;
研究者
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