A Danish Nationwide Longitudinal Study on Prevalence of Periodontitis and Its Co-morbidities

Not yet recruiting

• Conditions: Rheumatoid Arthritis; Periodontitis; Diabetes Mellitus, Type 2; Cardiovascular Diseases

• Registration Number: NCT05574231
• Lead Sponsor: University of Copenhagen

Brief Summary

The project (PlanPerioMed) is a register-based study evaluating the associations and patterns of health care delivery between periodontitis and medical diseases using data from the Danish dental record system Dentalsuite (Plandent A/S) and national Danish health care registries with three overall hypotheses/ aims:

* Determine the extent to which periodontitis in registry data is associated with more odontological treatment services and treatment frequency.

* Determine if patients with systemic diseases attend dentists more frequently and receive more treatment services per patient than the population without these diseases.

* Determine to which extent periodontitis and received periodontal treatment affects the risk of medical diseases.

The study will focus on association and trajectories of periodontitis and its treatment with three medical diseases, namely, Type 2 Diabetes Mellitus (Type 2 DM), Cardiovascular Diseases (CVD) and Rheumatoid Arthritis (RA). The dataset consists of approximately 4,000,000 people aged between 18 and 99 years attending private practice in Denmark. The results from PlanPerioMed study are likely to have ramifications for treatment guidelines for other periodontitis comorbidities, e.g. CVD and DM, and will thereby improve the quality of life for a wide range of patients and reduce long-term societal health care expenses related to periodontitis and its comorbidities.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-09-01
• Status Verified: 2022-10
• Study First Submitted QC: 2022-10-05
• Last Update Submitted: 2022-10-05
• Study First Posted: 2022-10-10
• Last Update Posted: 2022-10-10
• Study Start: 2022-11
• Primary Completion: 2025-12
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 4000000

Inclusion Criteria

• Subjects with clinical registrations of DMFT, periodontal status and corresponding treatment codes
• Self-reported systemic diseases including Diabetes Mellitus Type 2, Cardiovascular Diseases and Rheumatoid Arthritis
• Subjects with Clinical Attachment Loss>=3mm, Probing Depth >= 3mm and bleeding on probing (as defined by World Workshop 2017- criteria for periodontitis) in clinical examination will be included in the study population.

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Exclusion Criteria

• Subjects with more than 32 teeth
• Subjects with no clinical registrations

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Effect on medical diseases	25 years	Risk of medical diseases based on periodontal disease extent and received periodontal treatment
Treatment frequency and type of treatment services	25 years	Number of treatment and odontological treatment services due to periodontitis
Treatment frequency and type of treatment services among patients with medical diseases	25 years	Number of treatment and odontological treatment services among patients with medical diseases due to periodontitis