Genetic Predisposition for Chronic Non-specific Low Back Pain
- Conditions
- Low Back Pain
- Registration Number
- NCT02955407
- Lead Sponsor
- Balgrist University Hospital
- Brief Summary
Patients with inflammatory back pain were shown to differ from healthy controls in genotype of the Angiotensin-converting enzyme (ACE), which regulates vasoconstriction/-dilatation. The aim of this study is to investigate whether genetic reduction of muscle perfusion might be a pathophysiological pathway of how genes influence chronic non-specific low back pain (LBP).
- Detailed Description
The following genes will be investigated:
* Insertions-/deletions-polymorphism of the angiotensin-converting enzyme (ACE-I/D gene polymorphism; 3 genotypes: ACE-II, ACE-ID, ACE-DD).
* Anti-adhesive extracellular matrix protein Tenascin-C: gene polymorphism rs2104772
The goals of this study are to investigate whether these genotypes correlate with 1) endurance of back muscles, 2) comorbidities such as asthma and diabetes and 3) the risk for LBP as assessed by a LBP-classification tool.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
- 18-65
- Spinal surgery
- Spinal fracture
- Inflammation
- Tumour
- Severe chronic disease which make intensive physical activity impossible (osteoporosis, cardiovascular heart diseases)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Polymorphism ACE Gene baseline Polymorphism Tenascin Gene baseline
- Secondary Outcome Measures
Name Time Method Back muscle endurance in Sorensen test baseline
Trial Locations
- Locations (1)
Balgrist University Hospital
🇨🇭Zurich, Switzerland
Balgrist University Hospital🇨🇭Zurich, Switzerland