Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)
- Conditions
- Non-alcoholic Steatohepatitis
- Interventions
- Drug: Placebo
- Registration Number
- NCT04822181
- Lead Sponsor
- Novo Nordisk A/S
- Brief Summary
Semaglutide is a medicine studied in patients with NASH. Semaglutide is a well-known medicine, which is already used by doctors to treat type 2 diabetes in many countries.
Participants will either get semaglutide or a dummy medicine - which treatment participants get is decided by chance.
Participants will need to inject themselves with medicine under the skin. Participants will need to do this once a week.
The study will last for about 5 years. Participants will have up to 21 clinic visits and 9 phone calls with the clinical staff during the study. Some of the clinic visits may be spread over more than one day.
Participants with other chronic liver diseases cannot take part in this study. Women cannot take part in the study if they are pregnant, breast-feeding or plan to become pregnant during the study period.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 1205
- Age above or equal to 18 years at the time of signing informed consent.
- Histological evidence of NASH based on a central pathologist evaluation of the baseline liver biopsy. The baseline liver biopsy can be a historical biopsy obtained within 180 days prior to the screening visit (V1).
- Histological evidence of fibrosis stage 2 or stage 3 according to the NASH CRN (Clinical Research Network) classification based on a central pathologist evaluation of the baseline liver biopsy.
- A histological NAS (Non-alcoholic fatty liver disease Activity Score) above or equal to 4 with a score of 1 or more in steatosis, lobular inflammation and hepatocyte ballooning based on a central pathologist evaluation of the baseline liver biopsy.
- Documented causes of chronic liver disease other than non-alcoholic fatty liver disease (NAFLD)
- Positive HBsAg, positive anti-HIV, positive HCV RNA at screening (V2A) or any known presence of HCV RNA or HBsAg within 2 years of screening (V2A).
- Presence or history of ascites, variceal bleeding, hepatic encephalopathy, spontaneous bacterial peritonitis or liver transplantation at randomisation.
- Known or suspected excessive consumption of alcohol (greater than 20 g/day for women or greater than 30 g/day for men) or alcohol dependence (assessed by the Alcohol Use Disorders Identification Test (AUDIT questionnaire)).
- Treatment with vitamin E (at doses greater than or equal to 800 IU/day) or pioglitazone or medications approved for treatment of NASH which has not been at a stable dose in the period from 90 days prior to the screening visit (V2A). In addition, for subjects with historical liver biopsies taken more than 90 days prior to screening, treatment should be at a stable dose from time of biopsy until screening.
- Treatment with GLP-1 RAs in the period from 90 days prior to the screening visit (V2A). In addition, for subjects with historical liver biopsies taken more than 90 days prior to screening, any treatment with GLP-1 RAs from time of biopsy until screening (V2A).
- Treatment with glucose-lowering agent(s) (other than GLP-1 RAs), lipid-lowering medication or weight loss medication not stable in the opinion of the investigator in the period from 90 days prior to the screening visit (V2A). In addition, for subjects with historical liver biopsies taken more than 90 days prior to screening, treatment should be at a stable dose in the opinion of the investigator from time of biopsy until screening.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Semaglutide OW (once weekly ) Semaglutide Semaglutide administrated subcutaneously once weekly Placebo Placebo Placebo administrated subcutaneously once weekly
- Primary Outcome Measures
Name Time Method Part 1: Resolution of steatohepatitis and no worsening of liver fibrosis (Yes/No) From randomisation (week 0) to week 72 Count of subject
Part 1: Improvement in liver fibrosis and no worsening of steatohepatitis (Yes/No) From randomisation (week 0) to week 72 Count of subject
Part 2: Cirrhosis-free survival (Yes/No) From randomisation (week 0) to week 240 Count of subject
- Secondary Outcome Measures
Name Time Method Change in body weight From randomisation (week 0) to week 240 Percentage
Resolution of steatohepatitis and improvement in liver fibrosis (Yes/No) From randomisation (week 0) to week 72 Count of subject
Change in SF-36 (Short Form 36) Bodily Pain From randomisation (week 0) to week 72 Score points
Improvement in steatohepatitis with at least a 2-point reduction in NAS and no worsening of fibrosis (Yes/No) From randomisation (week 0) to week 72 Count of subject
Change in histology-assessed liver collagen proportionate area From randomisation (week 0) to week 72 Ratio to baseline
Worsening in steatohepatitis (Yes/No) From randomisation (week 0) to week 72 Count of subject
Improvement in histology-assessed ballooning (Yes/No) From randomisation (week 0) to week 72 Count of subject
Improvement in histology-assessed inflammation (Yes/No) From randomisation (week 0) to week 72 Count of subject
Improvement in histology-assessed steatosis (Yes/No) From randomisation (week 0) to week 72 Count of subject
NASH resolution (ballooning of 0, inflammation of 0-1) and above or equal to 2point NAS reduction with no worsening of fibrosis From randomisation (week 0) to week 72 Count of subject
Progression of liver fibrosis in patients with F2 at baseline (Yes/No) From randomisation (week 0) to week 72 Count of subject
Progression of liver fibrosis From randomisation (week 0) to week 72 Count of subject
Resolution of steatohepatitis and no worsening of liver fibrosis (Yes/No) From randomisation (week 0) to week 240 Count of subject
Improvement in liver fibrosis and no worsening of steatohepatitis (Yes/No) From randomisation (week 0) to week 240 Count of subject
Absence of histological evidence of NASH (Yes/No) From randomisation (week 0) to week 240 Count of subject
Changes in liver stiffness values assessed by transient elastography (FibroScan®) From randomisation (week 0) to week 72 and week 240 Ratio to baseline
Change in ELF (Enhanced Liver Fibrosis) score From randomisation (week 0) to week 72 and week 240 Logarithm
Change in ALT (alanine aminotransferase) From randomisation (week 0) to week 72 and week 240 Ratio to baseline
Change in AST (aspartate aminotransferase) From randomisation (week 0) to week 72 and week 240 Ratio to baseline
Change in CAP (Controlled Attenuation Parameter) values assessed by transient elastography (FibroScan) From randomisation (week 0) to week 72 and week 240 Absolute change
Change in FAST (FibroScan-AST) score From randomisation (week 0) to week 72 and week 240 Probability (absolute change)
Change in Pro-C3 (pro-peptide of type III collagen) From randomisation (week 0) to week 72 and week 240 Logarithm
Change in inflammation assessed by hsCRP (High Sensitive C-Reactive Protein) From randomisation (week 0) to week 72 and week 240 Ratio to baseline
Change in HbA1c (glycated haemoglobin) From randomisation (week 0) to week 72 and week 240 Percentage-points (absolute change)
Change in triglyceride From randomisation (week 0) to week 72 and week 240 Ratio to baseline
Change in free fatty acids From randomisation (week 0) to week 72 and week 240 Ratio to baseline
Change in LDL (low-density lipoprotein) cholesterol From randomisation (week 0) to week 72 and week 240 Ratio to baseline
Change in HDL (High density lipoprotein ) cholesterol From randomisation (week 0) to week 72 and week 240 Ratio to baseline
Time to first MACE(Major Adverse Cardiovascular event ) (composite endpoint) From randomisation (week 0) to week 240 Days
Major cardio-hepatic event-free survival (Yes/No) From randomisation (week 0) to week 240 Count of subject
Changes in SF-36 (Short Form 36 v2.0 acute ) Physical Component Summary From randomisation (week 0) to week 72 and week 240 Score points
Changes in SF-36 Mental Component Summary From randomisation (week 0) to week 72 and week 240 Score points
Change in SF-36 Bodily Pain From randomisation (week 0) to week 240 Score points
Changes in NASH-CHECK Abdominal Pain From randomisation (week 0) to week 72 and week 240 Score points
Trial Locations
- Locations (395)
The Diabetes Centre
🇬🇧Ipswich, United Kingdom
St. James University Hospital
🇬🇧Leeds, United Kingdom
SC Diamed Obesity SRL
🇷🇴Galati, Romania
Hvidovre Hospital - Gastroenheden
🇩🇰Hvidovre, Denmark
Hepatology St James's
🇮🇪Dublin, Ireland
Abdominal Center K, Research Unit
🇩🇰København NV, Denmark
Odense University Hospital
🇩🇰Odense C, Denmark
Centre Hospitalier Universitaire D'Angers-1
🇫🇷Angers, France
Ap-Hp-Hopital Beaujon
🇫🇷Clichy, France
Centre Hospitalier Universitaire de Lille-Hopital Claude Huriez
🇫🇷Lille, France
Centre Hospitalier Universitaire de Nice-Hopital de L'Archet 2
🇫🇷Nice, France
Aphp-Hopital La Pitie Salpetriere-4
🇫🇷Paris, France
Ap-Hp-Hopital Cochin
🇫🇷Paris, France
Prof. Dr. Schiefke Ingolf, EUGASTRO GmbH
🇩🇪Leipzig, Germany
Universitätsklinikum Leipzig - Klinik und Poliklinik für Onkologie, Gastroenterologie, Hepatologie und Pneumologie
🇩🇪Leipzig, Germany
Universitätsklinikum Schleswig-Holstein - Medizinischen Klinik I am Campus Lübeck
🇩🇪Lübeck, Germany
Universitätsmedizin der Johannes-Gutenberg-Universität Mainz - Hepatologie
🇩🇪Mainz, Germany
Gen Hospital of Athens Laiko,1st Dpt. of Propaedeutic Inter
🇬🇷Athens, Greece
General Hospital of Athens "LAIKO"
🇬🇷Goudi, Athens, Greece
AHEPA General University Hospital
🇬🇷Thessaloniki, Greece
General Hospital of Thessaloniki "Ippokrateio"
🇬🇷Thessaloniki, Greece
Yashoda Hospital
🇮🇳Secunderabad, Andhra Pradesh, India
Surat Institute of Digestive Science
🇮🇳Surat, Gujarat, India
Kasturba Medical College Hospitals (KMC Hospitals), Mangalore
🇮🇳Mangalore, Karnataka, India
Gleneagles Hospital, Super-speciality and Transplant Centre, Parel
🇮🇳Mumbai, Maharashtra, India
Seth GS medical college and KEM Hospital
🇮🇳Mumbai, Maharashtra, India
Midas Multispeciality Hospital
🇮🇳Nagpur, Maharashtra, India
Chung-Ang University Hospital
🇰🇷Seoul, Korea, Republic of
All India Institute of medical Sciences
🇮🇳Delhi, New Delhi, India
Institute of liver and Biliary Sciences
🇮🇳Ghitorni, New Delhi, India
Post Graduate Institute of Medical Education & Research_Chandigarh
🇮🇳Chandigarh, Punjab, India
SMG-SNU Boramae Medical Center
🇰🇷Seoul, Korea, Republic of
Korea University Guro Hospital
🇰🇷Seoul, Korea, Republic of
Dayanand Medical College & Hospital
🇮🇳Ludhiana, Punjab, India
Fortis Heart Institute and Multispeciality Hospital
🇮🇳Mohali, Punjab, India
S.R.Kalla Memorial Gastro & General Hospital
🇮🇳Jaipur, Rajasthan, India
Walter Reed Nat Mil Md Ctr
🇺🇸Bethesda, Maryland, United States
Centro de Investigaciones Metabólicas
🇦🇷Capital Federal, Argentina
Hospital El Cruce
🇦🇷Florencio Varela, Buenos Aires, Argentina
A.W. Morrow Gastroenterology and Liver Centre
🇦🇺Camperdown, New South Wales, Australia
Nepean Hospital
🇦🇺Kingswood, New South Wales, Australia
Westmead Hospital
🇦🇺Westmead, New South Wales, Australia
Griffith University Clinical Trial Unit
🇦🇺Southport, Queensland, Australia
SMS Super speciality Hospital, Department of Gastroenterology
🇮🇳Jaipur, Rajasthan, India
Beaumont Hospital
🇮🇪Dublin, Ireland
Carmel Medical Center Liver Unit
🇮🇱Haifa, Israel
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
Liver Unit, Hadassah Medical Center
🇮🇱Jerusalem, Israel
Liver Institute, Rabin Medical Center, Beilinson Campuse
🇮🇱Petah-Tikva, Israel
The Chaim Sheba Medical Center Liver Diseases Center
🇮🇱Ramat-Gan, Israel
Sourasky Medical Center Liver Unit
🇮🇱Tel Aviv, Israel
Azienda Ospedaliero-Universitaria Renato Dulbecco
🇮🇹Catanzaro, Cz, Italy
AOUP Giaccone Palermo
🇮🇹Palermo, Sicilia, Italy
Azieda Ospedaliero-Universitaria, Policlinico S. Orsola-Malp
🇮🇹Bologna, Italy
Osp Magg Policlinico Centro Malattie metaboliche del Fegato
🇮🇹Milano, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
🇮🇹Roma, Italy
Policlinico Università Campus Biomedico di Roma
🇮🇹Rome, Italy
Città della salute e della scienza - university of Torino
🇮🇹Torino, Italy
Juntendo University Hospital, Gastroenterology
🇯🇵Bunkyo-ku, Tokyo, Japan
The University of Tokyo Hospital, Gastroenterology
🇯🇵Bunkyo-ku, Tokyo, Japan
Fukui-ken Saiseikai Hospital, Internal Medicine
🇯🇵Fukui-shi, Fukui, Japan
Hoshi General Hospital_Gastroenterology
🇯🇵Fukushima, Japan
Gifu Municipal Hospital_Hepatology
🇯🇵Gifu, Japan
Ogaki Municipal Hospital_Gastroenterology and Hepatology
🇯🇵Gifu, Japan
Hamamatsu University Hospital
🇯🇵Hamamatsu-shi, Shizuoka, Japan
JA Hiroshima General Hospital
🇯🇵Hatsukaichi-shi, Hiroshima, Japan
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hosp.
🇯🇵Hiroshima-shi, Hiroshima, Japan
Lyell McEwin Hospital
🇦🇺Elizabeth Vale, South Australia, Australia
St Vincent's Hospital (Melbourne)
🇦🇺Fitzroy, Victoria, Australia
Hiroshima University Hospital
🇯🇵Hiroshima-shi, Hiroshima, Japan
Juntendo University Shizuoka Hospital
🇯🇵Izunokuni-shi, Shizuoka, Japan
Kagoshima University Hospital, Gastroenterology
🇯🇵Kagoshima-shi, Kagoshima, Japan
University Hospital Kyoto Prefectual University of Medicine
🇯🇵Kamigyo-ku, Kyoto, Japan
Kanazawa University Hospital
🇯🇵Kanazawa-shi, Ishikawa, Japan
Nara Medical University Hospital_Kashihara-shi, Nara
🇯🇵Kashihara-shi, Nara, Japan
Woodholme Gastroenterology Associates
🇺🇸Glen Burnie, Maryland, United States
Boston Medical Center_Cary
🇺🇸Boston, Massachusetts, United States
Southern Therapy and Advanced Research LLC
🇺🇸Jackson, Mississippi, United States
Clinical Research Professionals
🇺🇸Chesterfield, Missouri, United States
Kansas City Research Institute
🇺🇸Kansas City, Missouri, United States
Univ of Nebraska Medical CTR
🇺🇸Omaha, Nebraska, United States
Jubilee Clinical Research, Inc.
🇺🇸Las Vegas, Nevada, United States
Sierra Clinical Research-Las Vegas
🇺🇸Las Vegas, Nevada, United States
AIG Digestive Disease Research
🇺🇸Florham Park, New Jersey, United States
Premier Health Research, LLC
🇺🇸Sparta, New Jersey, United States
NYU Grossman School of Med
🇺🇸New York, New York, United States
Weill Cornell Med Coll-NYPH
🇺🇸New York, New York, United States
Icahn Sch of Med-Mt Sinai Hosp
🇺🇸New York, New York, United States
Austin Health
🇦🇺Heidelberg, Victoria, Australia
Fiona Stanley Hospital - Hepatology
🇦🇺Murdoch, Western Australia, Australia
Sir Charles Gairdner Hospital_Nedlands
🇦🇺Nedlands, Western Australia, Australia
Klinik Landstraße
🇦🇹Wien, Austria
CUB Hôpital Erasme_Brussels_0
🇧🇪Bruxelles, Belgium
Cliniques Universitaires Saint-Luc - Serv. Hépato-gastroentérology
🇧🇪Bruxelles, Belgium
Northeast GI Research Division
🇺🇸Concord, North Carolina, United States
AZ Maria Middelares - Gent - Gastro-Enterology
🇧🇪Gent, Belgium
Ohio State Univ Wexner Med Ctr
🇺🇸Columbus, Ohio, United States
Objective GI
🇺🇸Springboro, Ohio, United States
CRIOH
🇺🇸Westlake, Ohio, United States
Geisinger Clinic
🇺🇸Danville, Pennsylvania, United States
Pennsylvania State University
🇺🇸Hershey, Pennsylvania, United States
UZ Gent - Department Gastro-enterology
🇧🇪Gent, Belgium
University of Pennsylvania Hospital
🇺🇸Philadelphia, Pennsylvania, United States
Thomas Jefferson University Hospital
🇺🇸Philadelphia, Pennsylvania, United States
UPMC Center for Liver Diseases
🇺🇸Pittsburgh, Pennsylvania, United States
UPMC_Center for Liver Care
🇺🇸Pittsburgh, Pennsylvania, United States
Care Access Research, Pottsville
🇺🇸Pottsville, Pennsylvania, United States
Clinical Res Collaborative
🇺🇸Cumberland, Rhode Island, United States
Hospital das Clínicas da Universidade Federal de Goiás
🇧🇷Goiânia, Goias, Brazil
"UMHAT "Sveta Anna" Sofia" AD
🇧🇬Sofia, Bulgaria
Medical Center Synexus Sofia
🇧🇬Sofia, Bulgaria
WR-ClinSearch, LLC
🇺🇸Chattanooga, Tennessee, United States
Ocean St Clin Res Partnrs, LLC
🇺🇸Lincoln, Rhode Island, United States
Medical University Of South Carolina
🇺🇸Charleston, South Carolina, United States
Hospital de Clínicas de Porto Alegre_Porto Alegre
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Digestive Health Res-TSMC
🇺🇸Hermitage, Tennessee, United States
East Tennessee Research Institute
🇺🇸Johnson City, Tennessee, United States
Quality Medical Research
🇺🇸Nashville, Tennessee, United States
Amarillo Center for Clinical Research, Ltd.
🇺🇸Amarillo, Texas, United States
Hospital das Clínicas da Faculdade de Medicina de Botucatu
🇧🇷Botucatu, Sao Paulo, Brazil
St. Marianna University School of Medicine Hospital
🇯🇵Kawasaki-shi, Kanagawa, Japan
UMHAT "Sveta Marina"
🇧🇬Varna, Bulgaria
University of Calgary Liver Unit-(HMRC)
🇨🇦Calgary, Alberta, Canada
Texas Clin Res Inst, LLC
🇺🇸Arlington, Texas, United States
Liver Ins@ Mthdist DTX Med Cen
🇺🇸Dallas, Texas, United States
Velocity Clinical Res-Dallas
🇺🇸Dallas, Texas, United States
UT Southwestern Med Cntr
🇺🇸Dallas, Texas, United States
South Texas Research Institute
🇺🇸Edinburg, Texas, United States
Brooke Army Medical Ctr.
🇺🇸Fort Sam Houston, Texas, United States
GI Alliance Research
🇺🇸Fort Worth, Texas, United States
Bipharma Informatic Inc.
🇺🇸Houston, Texas, United States
Bylr Coll Md-Ben Taub Gen Hos
🇺🇸Houston, Texas, United States
Biopharma Informatic
🇺🇸Houston, Texas, United States
Fundação Pio XII - Hospital de Amor de Barretos
🇧🇷Barretos, São Paulo, Brazil
Kumamoto Shinto General Hospital
🇯🇵Kumamoto-shi, Kumamoto, Japan
Toranomon Hospital, Hepatology
🇯🇵Minato-ku, Tokyo, Japan
Japanese Red Cross Musashino Hospital
🇯🇵Musashino-shi, Tokyo, Japan
CIP Centro Integrado de Pesquisas do Hospital de Base
🇧🇷São José do Rio Preto, Sao Paulo, Brazil
Amir Ali Hassan, MD, PA
🇺🇸Houston, Texas, United States
Aichi Medical University Hospital
🇯🇵Nagakute-shi, Aichi, Japan
Assoc. Paulista para o Desenvolvimento da Medicina - UNIFESP
🇧🇷São Paulo, Sao Paulo, Brazil
Departamento de Gastroenterologia - HCFMUSP
🇧🇷São Paulo, Sao Paulo, Brazil
LinQ Research, LLC
🇺🇸Pearland, Texas, United States
Fundação Pio XII
🇧🇷Barretos, São Paulo, Brazil
Hospital Universitario Clementino Fraga Filho
🇧🇷Rio de Janeiro, Brazil
Rocco e Nazato Servicos Medicos LTDA
🇧🇷São Paulo, Brazil
"Acibadem City Clinic UMHAT Tokuda"
🇧🇬Sofia, Bulgaria
"Diagnostic - Consulting Center Aleksandrovska" EOOD
🇧🇬Sofia, Bulgaria
Heartlife Hospital
🇯🇵Nakagamigun, Okinawa, Japan
Nara City Hospital, Gastroenterology and Hepatology
🇯🇵Nara-shi, Nara, Japan
Amer. Rrsch Corp-TX Liver Inst
🇺🇸San Antonio, Texas, United States
Hyogo Medical University Hospital_Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine
🇯🇵Nishinomiya-shi, Hyogo, Japan
Oita Cardiovascular Hospital
🇯🇵Oita-shi, Oita, Japan
Kawasaki Medical School General Medical Center
🇯🇵Okayama-shi, Okayama, Japan
Osaka Metropolitan University Hospital, Department of Hepatology
🇯🇵Osaka-shi, Osaka, Japan
Japan Organization of Occupational Health and Safety Osaka Rosai Hospital_Gastroenterology
🇯🇵Osaka, Japan
Otsu City Hospital, Gastroenterological Medicine
🇯🇵Otsu-shi, Shiga, Japan
Saga University Hospital_Liver Center
🇯🇵Saga-shi, Saga, Japan
Japan Community Health care Organization Hokkaido Hospital
🇯🇵Sapporo-shi, Hokkaido, Japan
Sendai Kousei Hospital
🇯🇵Sendai-shi, Miyagi, Japan
Kagawa Prefectural Central Hospital
🇯🇵Takamatsu-shi, Kagawa, Japan
Tokyo Women's Medical University Hospital
🇯🇵Shinjuku-ku, Tokyo, Japan
Saiseikai Suita Hospital, Gastroenterology
🇯🇵Suita-shi, Osaka, Japan
Clinical Trials of Texas, LLC
🇺🇸San Antonio, Texas, United States
National Hospital Organization Takasaki General Medical Ctr.
🇯🇵Takasaki-shi, Gunma, Japan
Nihon University Itabashi Hospital
🇯🇵Tokyo, Japan
Ehime University Hospital
🇯🇵Toon-shi, Ehime, Japan
Saiseikai Wakayama Hospital
🇯🇵Wakayama-shi, Wakayama, Japan
Yokohama City University Hospital, Gastrointestinal Medicine
🇯🇵Yokohama-shi, Kanagawa, Japan
Kyungpook National University Hospital
🇰🇷Daegu, Korea, Republic of
Yeungnam Univ. Medical Center
🇰🇷Daegu, Korea, Republic of
Keimyung University Dongsan Hospital
🇰🇷Daegu, Korea, Republic of
Wonju Severance Christian Hospital
🇰🇷Gangwon-do, Korea, Republic of
SoonChunHyang University Hospital Bucheon
🇰🇷Gyeonggi-do, Korea, Republic of
Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
The First Affiliated Hospital, Sun Yat-sen University
🇨🇳Guangzhou, Guangdong, China
Digestive Hlth Res of N Texas
🇺🇸Wichita Falls, Texas, United States
South Ogden Family Medicine/ CCT Research
🇺🇸Ogden, Utah, United States
Inova Fairfax Medical Campus
🇺🇸Falls Church, Virginia, United States
Digestive and Liver Disease Specialists
🇺🇸Norfolk, Virginia, United States
Bon Secours Richmond Community Hospital LLC
🇺🇸Richmond, Virginia, United States
McGuire VA Medical Center
🇺🇸Richmond, Virginia, United States
VCU Health System
🇺🇸Richmond, Virginia, United States
Gastroent Consult of SW VA
🇺🇸Roanoke, Virginia, United States
Hospital Britanico de Buenos Aires
🇦🇷Ciudad de Buenos Aires, Buenos Aires, Argentina
DIM Clinica Privada
🇦🇷Buenos Aires, Argentina
Centro Médico Viamonte SRL
🇦🇷Caba, Argentina
Hospital Italiano Departamento Hepatologia
🇦🇷Caba, Argentina
Glenny Corp. S.A
🇦🇷Caba, Argentina
UMHAT "Sv. Ivan Rilski", Clinic of Gastroenterology
🇧🇬Sofia, Bulgaria
Spital Judetean De Urgenta Satu Mare
🇷🇴Satu Mare, Romania
"UMHAT "Tsaritsa Yoanna-ISUL"" EAD, Gastroenterology clinic
🇧🇬Sofia, Bulgaria
"DCC XX - Sofia" EOOD
🇧🇬Sofia, Bulgaria
GI Research Inst Foundation
🇨🇦Vancouver, British Columbia, Canada
Nova Scotia Hlth Halifax
🇨🇦Halifax, Nova Scotia, Canada
London Hlth Sci Ctr- Univ Camp
🇨🇦London, Ontario, Canada
Toronto Liver Centre
🇨🇦Toronto, Ontario, Canada
TDDA Specialty Research
🇨🇦Vaughan, Ontario, Canada
The First People's Hospital of Foshan-Infectious Disease
🇨🇳Foshan, Guangdong, China
Guangzhou First people's Hospital-Gastroenterology
🇨🇳Guangzhou, Guangdong, China
McGill University Health Centre
🇨🇦Montreal, Quebec, Canada
Hospital Fleurimont / CIUSS
🇨🇦Sherbrooke, Quebec, Canada
Ctr de Med Metab de Lanaudiere
🇨🇦Terrebonne, Quebec, Canada
Del Sol Research Management, LLC
🇺🇸Tucson, Arizona, United States
Beijing Friendship Hospital, Capital Medical University-Endocrinology
🇨🇳Beijing, Beijing, China
Beijing Ditan Hospital Capital Medical University-Hepatology
🇨🇳Beijing, Beijing, China
Peking University People's Hospital-(White Pagoda Temple Area)-Hepatopathy
🇨🇳Beijing, Beijing, China
Beijing You'an Hospital, Capital Medical University-Hepatology center
🇨🇳Beijing, Beijing, China
Beijing Tsinghua Changgung Hospital-Hepatology
🇨🇳Beijing, Beijing, China
Three Gorges Hospital Affiliated to Chongqing University-Endocrinology
🇨🇳Chongqing, Chongqing, China
Nanfang Hospital, Southern Medical University-Infectious Diseases
🇨🇳Guangzhou, Guangdong, China
The Third Affiliated Hospital, Sun Yat-sen University-Infectious
🇨🇳Guangzhou, Guangdong, China
Peking University Shenzhen Hospital
🇨🇳Shenzhen, Guangdong, China
The Third Hospital of Hebei Medical University-Hepatology
🇨🇳Shijiazhuang, Hebei, China
Hunan Provincial People's Hospital-Hepatology
🇨🇳Changsha, Hunan, China
Hunan Provincial People's Hospital
🇨🇳Changsha, Hunan, China
Changzhou No.2 People's Hospital
🇨🇳Changzhou, Jiangsu, China
THE Affiliated Hospital of Xuzhou Medical University（East）-Infectious Diseases
🇨🇳Xuzhou, Jiangsu, China
The First Bethune Hospital of Jilin University-Hepatic-biliary-pancrestic Medicine
🇨🇳Changchun, Jilin, China
General Hosp of Ningxia Medical University,Infectious Depart
🇨🇳Yinchuan, Ningxia, China
Jinan Central Hospital
🇨🇳Ji'nan, Shandong, China
Liaocheng People's Hospital-Infectious Diseases
🇨🇳Liaocheng, Shandong, China
Liaocheng People's Hospital
🇨🇳Liaocheng, Shandong, China
Qingdao Municipal Hospital (Group)-Infectious Diseases
🇨🇳Qingdao, Shandong, China
Shanghai Jiao Tong University School of Medicine Renji Hospital-Gastroenterology
🇨🇳Shanghai, Shanghai, China
Ruijin Hospital Affiliate to The Shanghai Jiaotong University-Infectious Diseases
🇨🇳Shanghai, Shanghai, China
Ruijin Hospital Affiliate to The Shanghai Jiaotong Universit
🇨🇳Shanghai, Shanghai, China
Shanghai Ninth People's Hospital-Infection Disease
🇨🇳Shanghai, Shanghai, China
Shanghai Ninth People's Hospital
🇨🇳Shanghai, Shanghai, China
West China Hospital Sichuan University-Infectious Diseases
🇨🇳Chengdu, Sichuan, China
Tianjin Third Central Hospital-Gastroenterology
🇨🇳Tianjin, Tianjin, China
The First Affiliated Hospital of WMU
🇨🇳Wenzhou, Zhejiang, China
Guangzhou Eighth People's Hospital-Hepatology
🇨🇳Guangzhou, China
Zhejiang Hospital-Infectious Diseases
🇨🇳Hangzhou, China
Hull Royal Infirmary_Hull
🇬🇧Hull, United Kingdom
The First Affiliated Hospital of Nanchang University
🇨🇳Nanchang, China
North AL Health Res, LLC
🇺🇸Huntsville, Alabama, United States
The Institute for Liver Health
🇺🇸Chandler, Arizona, United States
Inst-Liver Hlth dba AZ Liver H
🇺🇸Peoria, Arizona, United States
Inst. Liver H II dba AZ Liver H
🇺🇸Tucson, Arizona, United States
ARcare Center for Clinical Research
🇺🇸Jonesboro, Arkansas, United States
Arkansas Diagnostic Center, PA
🇺🇸Little Rock, Arkansas, United States
The Third People's Hospital of Shenzhen-Hepatology
🇨🇳Shenzhen, China
Gastroenterology & Liver Institute
🇺🇸Escondido, California, United States
UCSD NAFLD Research Center
🇺🇸La Jolla, California, United States
OM Research LLC
🇺🇸Oxnard, California, United States
Digestive Hlth Res of SoCa
🇺🇸Long Beach, California, United States
Cedars-Sinai Medical Center
🇺🇸Pasadena, California, United States
Pasedena Liver Center
🇺🇸Pasadena, California, United States
UC Davis Hlth -Midtwn Ambu Cen
🇺🇸Sacramento, California, United States
University of California, San Francisco
🇺🇸San Francisco, California, United States
Silicon Valley Res Inst
🇺🇸San Jose, California, United States
Peak Gastro Assoc-Col Springs
🇺🇸Colorado Springs, Colorado, United States
Yale Ctr for Clin Invest
🇺🇸New Haven, Connecticut, United States
Encore Medical Research of Boynton Beach LLC
🇺🇸Boynton Beach, Florida, United States
Integrity Clinical Research, LLC
🇺🇸Doral, Florida, United States
University of Florida-CTRB
🇺🇸Gainesville, Florida, United States
Direct Helpers Research Center
🇺🇸Hialeah, Florida, United States
Florida Research Institute, LLC
🇺🇸Lakewood Ranch, Florida, United States
Sandhill Research, LLC
🇺🇸Maitland, Florida, United States
Unidade Local De Saude De Gaia/Espinho E.P.E.
🇵🇹Vila Nova de Gaia, Portugal
Tandem Clinical Research - Maitland
🇺🇸Maitland, Florida, United States
Optimus U, Corp
🇺🇸Miami, Florida, United States
Univ of Miami/Schiff Ctr
🇺🇸Miami, Florida, United States
Genoma Research Group, Inc
🇺🇸Miami, Florida, United States
IMIC Inc
🇺🇸Miami, Florida, United States
Ocala GI Research
🇺🇸Ocala, Florida, United States
Sensible Healthcare LLC
🇺🇸Ocoee, Florida, United States
Headlands Research - Sarasota
🇺🇸Sarasota, Florida, United States
ClinCloud, LLC
🇺🇸Viera E., Florida, United States
The Third People's Hospital of Shenzhen
🇨🇳Shenzhen, China
Tianjin Second People's Hospital-Liver Disease Department III
🇨🇳Tianjin, China
Klinicki bolnicki centar Osijek
🇭🇷Osijek, Croatia
KBC Rijeka, Zavod za gastroenterologiju
🇭🇷Rijeka, Croatia
Florida Medical Clinic Orlando Health
🇺🇸Zephyrhills, Florida, United States
Columbus Regional Research Institute
🇺🇸Columbus, Georgia, United States
Gastroenterology Assoc_ CGA
🇺🇸Macon, Georgia, United States
Gastroint Spec of Georgia
🇺🇸Marietta, Georgia, United States
Endeavor Health
🇺🇸Skokie, Illinois, United States
Digestive Research Alliance of Michiana
🇺🇸South Bend, Indiana, United States
Iowa Digestive Disease Center
🇺🇸Clive, Iowa, United States
University Of Kansas Hospital
🇺🇸Kansas City, Kansas, United States
Kansas Medical Clinic, PA
🇺🇸Topeka, Kansas, United States
Tandem Clinical Research
🇺🇸Marrero, Louisiana, United States
Tandem Clinical Research - Metairie
🇺🇸Metairie, Louisiana, United States
Louisiana Research Center, LLC
🇺🇸Shreveport, Louisiana, United States
Mercy Medical Center, GI Research
🇺🇸Baltimore, Maryland, United States
KBC Split/ Firule/ Gastroenterologija
🇭🇷Split, Croatia
KB Dubrava, Zavod za gastroenterologiju
🇭🇷Zagreb, Croatia
Klinički bolnički centar Zagreb, Zavod za gastroenterologiju
🇭🇷Zagreb, Croatia
Krajská nemocice Liberec, a.s
🇨🇿Liberec, Czechia
Fakultni nemocnice Plzen - Lochotin
🇨🇿Plzen, Czechia
Researchsite s.r.o.
🇨🇿Plzeň, Czechia
Vseobecna Fakultni nemocnice v Praze
🇨🇿Prague 2, Czechia
Aarhus Universitetshospital Skejby Mave-Tarm
🇩🇰Aarhus N, Denmark
Hospital Universiti Sains Malaysia
🇲🇾Kota Bharu, Kelantan, Malaysia
University Malaya Medical Centre
🇲🇾Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia
Hospital Selayang
🇲🇾Batu Caves, Malaysia
Centro de Investigacion Clinica del Pacifico, S.A. de C.V.
🇲🇽Acapulco de Juarez, Guerrero, Mexico
FDI Clinical Research
🇵🇷San Juan, Puerto Rico
Centro de Investigación Médico Biológica y Terapia
🇲🇽Guadalajara, Jalisco, Mexico
Centro de Investigación y Gastroenterología, S.C.
🇲🇽Ciudad de México, México, D.F., Mexico
Servicios de Oncologia Medica Integral S.A de C.V (ONCARE)
🇲🇽San Pedro Garza Garcia, Nuevo Leon, Mexico
Investigaciones Médicas Cisneros, S.C.
🇲🇽Monterrey, Nuevo León, Mexico
Hospital Angeles de Culiacan
🇲🇽Culiacan, Sinaloa, Mexico
Medical Care and Research S. A de C.V
🇲🇽Merida, Yucatan, Mexico
Centro de Investigación y Gastroenterología_ Hospital Angeles Universidad
🇲🇽Mexico, Mexico
Noordwest Ziekenhuisgroep
🇳🇱Alkmaar, Netherlands
Academisch Medisch Centrum
🇳🇱Amsterdam, Netherlands
Leids Universitair Medisch Centrum
🇳🇱Leiden, Netherlands
Bærum sykehus
🇳🇴Gjettum, Norway
Oslo universitetssykehus, Ullevål
🇳🇴Oslo, Norway
ID Clinic Arkadiusz Pisula
🇵🇱Mysłowice, Malopolskie, Poland
Gizinscy Centrum Medyczne
🇵🇱Bydgoszcz, Poland
BodyClinic
🇵🇱Warszawa, Poland
Centrum Badan Klinicznych
🇵🇱Wroclaw, Poland
FutureMeds Sp. z o.o.
🇵🇱Wrocław, Poland
Ko-Med Centra Kliniczne Staszow
🇵🇱Staszow, Świętokrzyskie, Poland
Velocity Nova Sp. z o.o.
🇵🇱Staszow, Świętokrzyskie, Poland
Unidade Local De Saude De Matosinhos E.P.E.
🇵🇹Senhora Da Hora, Matosinhos, Matosinhos, Portugal
Hospital Garcia de Orta
🇵🇹Almada, Portugal
Unidade Local De Saude De Almada-Seixal E.P.E.
🇵🇹Almada, Portugal
Hospital de Braga
🇵🇹Braga, Portugal
Unidade Local De Saude Da Guarda E.P.E. - Hospital Sousa Martins
🇵🇹Guarda, Portugal
APDP - Associação Protectora dos Diabéticos de Portugal
🇵🇹Lisboa, Portugal
Unidade Local De Saude De Santa Maria E.P.E.
🇵🇹Lisboa, Portugal
Unidade Local de Saúde de Santo António, E.P.E
🇵🇹Porto, Portugal
Unidade Local de Saúde do Alto Minho E.P.E. - Viana do Castelo
🇵🇹Viana do Castelo, Portugal
Hospital Luz Arrabida, S.A.
🇵🇹Vila Nova de Gaia, Portugal
Volosevich First City Clinical Hospital
🇷🇺Arkhangelsk, Russian Federation
Kazan Federal University
🇷🇺Kazan, Russian Federation
Friendship University of Russia
🇷🇺Moscow, Russian Federation
Limited Law Company "Healthy Family" Medicine Center"
🇷🇺Novosibirsk, Russian Federation
Joint Stock Company "Polyclinic Complex"
🇷🇺Saint Petersburg, Russian Federation
Limited Liability Company "Energiya Zdoroviya"
🇷🇺Saint-Petersburg, Russian Federation
North-Western State Medical Univer. based on Med-Prof Center
🇷🇺Saint-Petersburg, Russian Federation
Consultative & Diagnostic Center with a Outpatient Hospital
🇷🇺Saint-Petersburg, Russian Federation
Ulianovsk Regional Clinical Hospital
🇷🇺Ulianovsk, Russian Federation
Polyclinic #2 in Yoshkar-Ola
🇷🇺Yoshkar-Ola, Russian Federation
Clin. Centre Vojvodina, Clin. endocr., diab. and met. dis.
🇷🇸Novi Sad, Vojvodina, Serbia
Clinic for gastroenterology and hepatology
🇷🇸Belgrade, Serbia
Clinical-hospital centre Zvezdara
🇷🇸Belgrade, Serbia
National University Hospital_TBD
🇸🇬Singapore, Singapore
Singapore General Hospital
🇸🇬Singapore, Singapore
Changi General Hospital
🇸🇬Singapore, Singapore
Nemocnica akademika L. Derera, UNB
🇸🇰Bratislava, Slovakia
MEDISPEKTRUM s.r.o.
🇸🇰Bratislava, Slovakia
Phoenix Pharma
🇿🇦Port Elizabeth, Eastern Cape, South Africa
Chris Hani Baragwanath Hospital
🇿🇦Johannesburg, Gauteng, South Africa
WITS Clinical Research
🇿🇦Johannesburg, Gauteng, South Africa
Lenasia Clinical Trial Centre
🇿🇦Lenasia, Gauteng, South Africa
Maxwell Centre
🇿🇦Durban, KwaZulu-Natal, South Africa
Tiervlei Trial Centre
🇿🇦Cape Town, Western Cape, South Africa
Dr Rajabally's Practice
🇿🇦Cape Town, Western Cape, South Africa
Wits Health Consortium
🇿🇦Johannesburg, South Africa
Complejo Hospitalario de Pontevedra - Hospital de Montecelo
🇪🇸Pontevedra, Spain
Hospital Vall d'Hebron
🇪🇸Barcelona, Spain
Hospital Universitario Puerta de Hierro Majadahonda
🇪🇸Majadahonda, Spain
Hospital Universitario Marqués de Valdecilla
🇪🇸Santander, Spain
Hospital Universitario Virgen del Rocío
🇪🇸Sevilla, Spain
Hospital Universitario y Politécnico La Fe
🇪🇸Valencia, Spain
Hospital Clínico de Valladolid
🇪🇸Valladolid, Spain
Universitätsklinik für Viszerale Chirurgie und Medizin
🇨🇭Bern, Switzerland
Hôpitaux Universitaires de Genève
🇨🇭Geneva, Switzerland
Kantonsspital Olten
🇨🇭Olten, Switzerland
Kantonsspital St. Gallen
🇨🇭St. Gallen, Switzerland
Ditmanson Medical Foundation Chia-Yi Christian Hospital
🇨🇳Chiayi City, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
🇨🇳Kaohsiung, Taiwan
Taipei Tzu Chi Hospital
🇨🇳New Taipei City, Taiwan
National Cheng Kung University Hospital
🇨🇳Tainan City, Taiwan
Taipei-Veterans General Hospital - Dept of Gastrointestinal
🇨🇳Taipei city, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
T.C. Saglık Bakanlıgı Adana Sehir Egitim ve Arastirma Hastan
🇹🇷Adana, Turkey
Ankara Universitesi Tıp Fakultesi Gastroenteroloji Bilim Da
🇹🇷Ankara, Turkey
Ankara Sehir Hastanesi,Gastroenteroloji Klinigi
🇹🇷Ankara, Turkey
Uludag Universitesi Tıp Fakultesi-Gastroenteroloji
🇹🇷Bursa, Turkey
Koc Universitesi Hastanesi-Gastroenteroloji
🇹🇷Istanbul, Turkey
Bezmialem Vakif Universitesi Tip Fakultesi Hastanesi-Gastroe
🇹🇷Istanbul, Turkey
Marmara Univ. Pendik Gastroenterology
🇹🇷Istanbul, Turkey
Ege Universitesi Tip Fakultesi Hastanesi, Gastroenteroloji
🇹🇷Izmir, Turkey
Kocaeli Universitesi Tıp Fakültesi Gastroenteroloji ve Hepat
🇹🇷Kocaeli, Turkey
Mersin Universitesi Tip Fakultesi Gastroenteroloji Bilim Dal
🇹🇷Mersin, Turkey
New Queen Elizabeth Hospital Birmingham
🇬🇧Birmingham, United Kingdom
Royal Derby Hospital
🇬🇧Derby, United Kingdom
Ninewells Hospital
🇬🇧Dundee, United Kingdom
Royal Devon University Healthcare NHS Foundation Trust
🇬🇧Exeter, United Kingdom
Royal Free - Immunity & Transplantation
🇬🇧London, United Kingdom
Chelsea & Westminster Hospital
🇬🇧London, United Kingdom
Imperial College London
🇬🇧London, United Kingdom
Freeman Hospital, Newcastle
🇬🇧Newcastle-Upon Tyne, United Kingdom
Nottingham University Hospital
🇬🇧Nottingham, United Kingdom
John Radcliffe Hospital
🇬🇧Oxford, United Kingdom
Derriford Hospital
🇬🇧Plymouth, United Kingdom
Southampton General Hospital
🇬🇧Southampton, United Kingdom
Joint Clinical Research Facility - Swansea
🇬🇧Swansea, United Kingdom