Parkinson's Research: The Organized Genetics Initiative
- Conditions
- Parkinson Disease
- Registration Number
- NCT00086073
- Lead Sponsor
- Indiana University School of Medicine
- Brief Summary
The purpose of this trial is to study genetic and other risk factors that may be important in the development of Parkinson's disease.
- Detailed Description
The The Parkinson's Research: The Organized Genetics Initiative, also known as PROGENI, is a multi-center study involving 2000 people throughout North America who are affected, or possibly affected, with Parkinson's disease (PD). The goal of the initiative is to study the genetic and other risk factors which may be important in the development of PD.
In order to better understand the genetic factors leading to PD, researchers will study families having 2 or more members diagnosed with PD. Using DNA samples from each participant, researchers hope to identify genes that may cause a person to be at higher risk for developing PD.
Each participant in the study will be asked to complete a family history questionnaire, providing information about the history of PD in the family. Participants also will be asked to discuss the symptoms they have experienced and their responses to PD medications. This information will be used by study personnel to determine further eligibility for the study. Those eligible for further participation will be asked to undergo a study visit at the site closest to their residence, during which they will be asked to complete questionnaires regarding PD symptoms, medical history, places of residence, occupations, mood, mental status, and activity level. A blood sample will be drawn for DNA extraction. The study visit will take about 2 hours.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1800
- To be eligible to participate in this study participants must be diagnosed with or have symptoms of PD. In addition, they must also have a family history of PD in other relatives.
- Subjects cannot have participated in any other genetic research project for Parkinson's disease.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (57)
University of Chicago
🇺🇸Chicago, Illinois, United States
Port City Neurology, Inc
🇺🇸Scarborough, Maine, United States
University of Maryland School of Medicine
🇺🇸Baltimore, Maryland, United States
Johns Hopkins University
🇺🇸Baltimore, Maryland, United States
Brigham & Women's Hospital
🇺🇸Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center
🇺🇸Boston, Massachusetts, United States
Parkinson's & Movement Disorder Institute
🇺🇸Fountain Valley, California, United States
Pacific Neuroscience Medical Group, Inc
🇺🇸Oxnard, California, United States
University of California Irvine
🇺🇸Irvine, California, United States
Colorado Neurological Institute
🇺🇸Englewood, Colorado, United States
Parkinson's Disease & Mmvt Disorders Ctr of Boca Raton
🇺🇸Boca Raton, Florida, United States
Northwestern University Medical School
🇺🇸Chicago, Illinois, United States
Mayo Clinic Jacksonville
🇺🇸Jacksonville, Florida, United States
Medical College of Georgia
🇺🇸Augusta, Georgia, United States
Cleveland Clinic Florida
🇺🇸Weston, Florida, United States
Evanston Northwestern Healthcare
🇺🇸Evanston, Illinois, United States
LSU Health Sciences Center
🇺🇸Shreveport, Louisiana, United States
Kansas University Medical Center
🇺🇸Kansas City, Kansas, United States
Southern Illinois Univ School of Medicine
🇺🇸Springfield, Illinois, United States
University of Iowa
🇺🇸Iowa City, Iowa, United States
Henry Ford Health System
🇺🇸Southfield, Michigan, United States
Washington University
🇺🇸St. Louis, Missouri, United States
Albany Medical College
🇺🇸Albany, New York, United States
Michigan State University
🇺🇸East Lansing, Michigan, United States
University of Buffalo
🇺🇸Buffalo, New York, United States
Beth Israel Medical Center
🇺🇸New York, New York, United States
Mount Sinai Medical Center
🇺🇸New York, New York, United States
Columbia-Presbyterian Medical Center
🇺🇸New York, New York, United States
Ohio State University
🇺🇸Columbus, Ohio, United States
Medical College of Ohio, ,
🇺🇸Toledo, Ohio, United States
UT Southwestern Medical Center
🇺🇸Dallas, Texas, United States
Neurohealth
🇺🇸Warwick, Rhode Island, United States
University of Tennessee-Health Sciences Center
🇺🇸Memphis, Tennessee, United States
London Health Sciences Center
🇨🇦London, Ontario, Canada
Ottawa Civic Hospital
🇨🇦Ottawa, Ontario, Canada
Toronto Western Hospital
🇨🇦Toronto, Ontario, Canada
Hotel-Dieu Hospital-CHUM
🇨🇦Montreal, Quebec, Canada
University of Puerto Rico School of Medicine
🇵🇷San Juan, Puerto Rico
Cleveland Clinic Foundation
🇺🇸Cleveland, Ohio, United States
Baylor College of Medicine
🇺🇸Houston, Texas, United States
University of Colorado Health Sciences Center
🇺🇸Denver, Colorado, United States
Institute for Neurodegenerative Disorders
🇺🇸New Haven, Connecticut, United States
University of South Florida
🇺🇸Tampa, Florida, United States
Indiana University School of Medicine
🇺🇸Indianapolis, Indiana, United States
Barrow Neurological Institute
🇺🇸Phoenix, Arizona, United States
University of California San Diego
🇺🇸San Diego, California, United States
University of California San Francisco
🇺🇸San Francisco, California, United States
Oschsner Clinic Foundation
🇺🇸New Orleans, Louisiana, United States
University of Minnesota Fairview Univ Med Ctr
🇺🇸Minneapolis, Minnesota, United States
Wake Forest University School of Medicine
🇺🇸Winston-Salem, North Carolina, United States
University of Cincinnati Medical Center
🇺🇸Cincinnati, Ohio, United States
Oregon Health & Science University
🇺🇸Portland, Oregon, United States
University of Pittsburg
🇺🇸Pittsburg, Pennsylvania, United States
Medical College of Wisconsin
🇺🇸Milwaukee, Wisconsin, United States
University of Alberta
🇨🇦Edmonton, Alberta, Canada
Pacific Health Research Institute
🇺🇸Honolulu, Hawaii, United States
University of Rochester Medical Center
🇺🇸Rochester, New York, United States