Relationship Between NLR and Prealbumin Levels With Diaphragm Thickness

Completed

• Conditions: Inflammatory Response
• Interventions: Diagnostic Test: Ratio of Neutrophil to Lymphocyte; Diagnostic Test: Level of Prealbumin Serum

• Registration Number: NCT04014439
• Lead Sponsor: Indonesia University

Brief Summary

A study to find the relationship between neutrophil to lymphocyte ratio (NLR) with diaphragm thickness of critical patients in ICU.

Detailed Description

Weaning from ventilator sometimes can be failed and it happened due to several factors. One of the causes was Ventilator Induced Diaphragm Dysfunction (VIDD). This VIDD process occurred due to thinning process of the diaphragm thickness or decreased diaphragm muscle mass. The whole process happened due to inflammatory reaction that usually appeared on patients in Intensive Care Unit (ICU). Thus, this study was aimed to find the relationship between neutrophil to lymphocyte ratio (NLR) with diaphragm thickness of critical patients in ICU.

Study Timeline

• Study First Submitted: 2019-07-08
• Study First Submitted QC: 2019-07-08
• Study First Posted: 2019-07-10
• Study Start: 2019-09-01
• Status Verified: 2019-12
• Primary Completion: 2019-12-01
• Study Completion: 2019-12-01
• Last Update Submitted: 2019-12-30
• Last Update Posted: 2020-01-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Critical patients treated in intensive care unit using mechanical ventilation from day 0.
• Patients are clinically predicted to be treated for more than 5 days (qSOFA and clinical assessment)

Exclusion Criteria

• History of suffering from neuromuscular disease and or diaphragmatic malformations
• Used non-invasive ventilation before starting to use mechanical ventilation
• History of tracheostomy
• Patients admitted to ICU within 12 months before this study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Normal Diaphragm	Level of Prealbumin Serum	Diaphragm thickness is 2 mm or more
Thinning Diaphragm	Level of Prealbumin Serum	Diaphragm thickness is less than 2 mm
Normal Diaphragm	Ratio of Neutrophil to Lymphocyte	Diaphragm thickness is 2 mm or more
Thinning Diaphragm	Ratio of Neutrophil to Lymphocyte	Diaphragm thickness is less than 2 mm

Primary Outcome Measures

Name	Time	Method
Level of Prealbumin Serum	5 days
Ratio of Neutrophil to Lymphocyte	5 days

Trial Locations

Locations (1)

Indonesia University; 🇮🇩 Jakarta Pusat, DKI Jakarta, Indonesia