Respiratory System Mechanics and Gas Exchange Characteristics Applying Different Ventilatory Strategies in Patients With SARS-CoV-2
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Covid19
- Sponsor
- Sanatorio Anchorena San Martin
- Enrollment
- 15
- Locations
- 1
- Primary Endpoint
- Driving transpulmonary pressure (cmH2O)
- Last Updated
- 5 years ago
Overview
Brief Summary
The combination of different ventilatory strategies and its effects on respiratory mechanics and gas exchange in patients under mechanical ventilation with acute respiratory distress syndrome secondary to coronavirus-19 has been scarcely described.
Detailed Description
Investigation in mechanically ventilated patients with with acute respiratory distress syndrome (ARDS) secondary to coronavirus-19 (COVID-19) is emerging due to presumed differences with typical ARDS from other origin. Considering these issues, the effects of ventilatory strategies such as positive end expiratory pressure, end inspiratory pause and fraction of inspired oxygen on respiratory mechanics and gas exchange must be studied in order to characterize the behavior of COVID-19 ARDS during invasive mechanical ventilation and choose the best combination of ventilatory settings. In this study the investigators will evaluate the changes in respiratory mechanics and gas exchange produced by low and high positive end expiratory pressure, low and high inspired oxygen fraction and the application of end inspiratory pause during volume controlled mechanical ventilation.
Investigators
Matias Accoce
Head of physical therapy department
Sanatorio Anchorena San Martin
Eligibility Criteria
Inclusion Criteria
- •Older than 18 years old
- •less than 72 hs since ARDS diagnosis
- •Moderate to severe ARDS
- •central venous catheter and arterial line available
- •Need of neuromuscular blocking agents
- •Supine position
- •Informed consent accepted
- •Airway opening pressure lower than 20 cmH2O
Exclusion Criteria
- •RASS target higher than -5
- •COPD diagnosis
- •Pneumothorax
- •Intracraneal Hypertension
- •Pregnancy
- •Cardiac inssuficiency uncompensated
- •Chest wall deformity
- •Bronchopleural fistula
- •Contraindication to use esophageal manometry
Outcomes
Primary Outcomes
Driving transpulmonary pressure (cmH2O)
Time Frame: 10 minutes
The driving transpulmonary pressure will be evaluated between the high and low PEEP condition using the formula: driving transpulmonary pressure = driving airway pressure - driving esophageal pressure (cmH2O).
Bohr dead space fraction (%)
Time Frame: 10 minutes
The Bohr dead space fraction will be evaluated with high PEEP between the condition with end inspiratory pause and with no end inspiratory pause application using the formula: Bohr dead space fraction = Alveolar pressure of CO2 (PACO2) - Expired pressure of CO2 (PECO2) / PACO2
Shunt fraction (%)
Time Frame: 10 minutes
The shunt fraction will be evaluated with low PEEP between the condition with high fraction of oxygen to achieve a saturation goal of 96-98% and the condition with low fraction of oxygen to achieve a saturation goal of 88-92%. The shunt fraction will be calculated using the formula: Qs/Qt = (capillary oxygen content - arterial oxygen content)/(capillary oxygen content - venous oxygen content)