The Effect of Diluted Sodium Hypochlorite Solution and Moisturizers on Skin Barrier Function in Atopic Dermatitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Change in transepidermal water loss post-bath immersion
研究概览
简要总结
The goal is this study is to investigate the effects of dilute bleach on the skin of subjects with atopic dermatitis and those with healthy skin. The second goal is to evaluate the effects of different moisturizers on the skin barrier of subjects with and without atopic dermatitis. The investigators hypothesize that the bleach bath will increase the skin pH, decrease the skin hydration, and increase skin water loss in all study subjects. Secondly, the investigators hypothesize that moisturizers with the lowest pH and the highest water to oil ratio will result in improved skin barrier function. Furthermore, the investigators believe there will be a greater improvement in patients with atopic dermatitis.
详细描述
The study has two main parts. Subjects in both groups will have one forearm in a dilute bleach bath and the other arm in a water bath for 10 minutes. The change in skin will be measured using different painless devices. The second part of the study involves application of 4 various moisturizers. The change in skin will be measured over a period of time using the non-invasive devices.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 8 Years 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 8 years to 65 years
- •Has been diagnosed with atopic dermatitis by a board-certified dermatologist at UC Davis
- •Subject/parents/legal guardians able to read and comprehend the study procedure and consent forms.
排除标准
- •Those who are pregnant, prisoners, or cognitively impaired
- •Those who do not fit the inclusion criteria
结局指标
主要结局
Change in transepidermal water loss post-bath immersion
时间窗: 10 minutes post-bath immersion
Subjects will immerse one randomized arm in a bleach bath and the other arm in a water bath for 10 minutes. The skin barrier function will be evaluated for change in transepidermal water loss after 10 minutes of bath immersion.
次要结局
- Change in skin hydration after moisturizer application(up to 60 minutes post-moisturizer application)
- Change in skin pH after moisturizer application(up to 60 minutes post-moisturizer application)
- Change in skin pH post-bath immersion(10 minutes post-bath immersion)
- Change in skin hydration post-bath immersion(10 minutes post-bath immersion)
- Change in transepidermal water loss after moisturizer application(up to 60 minutes post-moisturizer application)