Effects of dispersible vitamin D and B12 supplementation in vitamin D and B12 insufficiency

Not Applicable

Not yet recruiting

• Conditions: vitamin D deficiency; vitaminB12 deficiency; Diet and Nutrition - Other diet and nutrition disorders

• Registration Number: ACTRN12624000468527
• Lead Sponsor: icholaos Angelopoulos,MD,Phd

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-04-16
• Last Update Posted: 22 April 2024

Recruitment & Eligibility

• Status: Not yet recruiting
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

Patients with serum vitamin d levels lower than 25 ng/dl and b12 levels lower than 250 ng/

Exclusion Criteria

1.individuals who have been taking vitamin D supplements regularly or at high doses prior to the study.
2.Medications affecting vitamin D metabolism: Exclude individuals who are taking medications known to interfere with vitamin D metabolism or absorption, such as antiepileptic drugs (phenytoin, phenobarbital), glucocorticoids (prednisone), or certain weight-loss medications (orlistat).
3.Chronic kidney disease
4.Other metabolic disorders: individuals with specific metabolic disorders that could impact vitamin D metabolism or lead to altered vitamin D levels, such as primary hyperparathyroidism, hyperthyroidism, or malabsorption syndromes (e.g., celiac disease, Crohn's disease).
5.Conditions that significantly affect bone health, such as osteoporosis, osteomalacia, or Paget's disease.
6.Pregnancy and breastfeeding
7.Severe illnesses or comorbidities: terminal cancer, uncontrolled diabetes, or autoimmune disorders.
8. Drugs that affect vitamin b12 metabolism: Drugs
• Alcohol
• Nitrous oxide
• Proton pump inhibitors
• H2 receptor antagonists
• Metformin
• Colchicine
• Slow K (potassium chloride) preparations
• Cholestyramine
9. History of bariatric surgery and/or stomach operation

Study & Design

• Study Type: Interventional
• Study Design: Not specified