Circulating Biomarkers as Prognostic Indicators of Death in Ambulatory Heart Failure Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 124
- 试验地点
- 1
研究概览
简要总结
Biomarkers representing distinct biological domains including neurohormonal, inflammatory, metabolic-nutritional, oxidative-nitrosative and myocardial injury, might alone or in combination provide prognostic information on mortality in heart failure patients with preserved or impaired systolic function.
详细描述
Upon enrollment in the study, Troponin I (cTn I), BNP, norepinephrine, plasma renin activity, aldosterone, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), soluble receptor of interleukin 2 (sIL-2R), leptin, prealbumin, free malondialdehyde, 15-F2t-isoprostane and protein-bound nitrotyrosine were measured in stable ambulatory, non diabetic, elderly heart failure patients. Patients were followed up until death or study termination (31st January 2009).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •symptomatic congestive heart failure lasting at least six months
- •reduced exercise tolerance
- •impaired or preserved left ventricular ejection fraction
- •cardiomegaly
排除标准
- •acute infection
- •rheumatoid or other autoimmune diseases
- •primary cachectic states (cancer, thyroid disease, severe liver disease)
- •severe chronic lung disease
- •neuromuscular disorders
- •myocardial infarction within the previous 20 weeks
- •diabetes mellitus
- •chronic renal failure (serum creatinine level > 2.0 mg/dl, >177 micromol/L)