Circulating Biomarkers as Prognostic Indicators of Death in Ambulatory Heart Failure Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Heart Failure
- Sponsor
- University of Parma
- Enrollment
- 124
- Locations
- 1
- Status
- Completed
- Last Updated
- 16 years ago
Overview
Brief Summary
Biomarkers representing distinct biological domains including neurohormonal, inflammatory, metabolic-nutritional, oxidative-nitrosative and myocardial injury, might alone or in combination provide prognostic information on mortality in heart failure patients with preserved or impaired systolic function.
Detailed Description
Upon enrollment in the study, Troponin I (cTn I), BNP, norepinephrine, plasma renin activity, aldosterone, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), soluble receptor of interleukin 2 (sIL-2R), leptin, prealbumin, free malondialdehyde, 15-F2t-isoprostane and protein-bound nitrotyrosine were measured in stable ambulatory, non diabetic, elderly heart failure patients. Patients were followed up until death or study termination (31st January 2009).
Investigators
Eligibility Criteria
Inclusion Criteria
- •symptomatic congestive heart failure lasting at least six months
- •reduced exercise tolerance
- •impaired or preserved left ventricular ejection fraction
- •cardiomegaly
Exclusion Criteria
- •acute infection
- •rheumatoid or other autoimmune diseases
- •primary cachectic states (cancer, thyroid disease, severe liver disease)
- •severe chronic lung disease
- •neuromuscular disorders
- •myocardial infarction within the previous 20 weeks
- •diabetes mellitus
- •chronic renal failure (serum creatinine level \> 2.0 mg/dl, \>177 micromol/L)
Outcomes
Primary Outcomes
Not specified