The Use of Tranexamic Acid (TXA) Intravenously, to Reduce Blood Loss in Proximal Femur Surgery
Overview
- Phase
- Phase 4
- Status
- Withdrawn
- Locations
- 1
- Primary Endpoint
- Evaluation of blood loss in ml.
Overview
Brief Summary
The use of Tranexamic Acid (TXA) intravenously, to Reduce Blood Loss in proximal femur surgery.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Ages
- 60 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients over 60, who came to the orthopedic department for proximal femur fracture surgery
- •Sound judgment
Exclusion Criteria
- •Known hypersensitivity to Tranexamic Acid or component solution provided
- •Subarachnoid hemorrhage
- •Acquired color blindness
- •Myocardial infarction in 12 months before admission
- •Unstable angina
- •Known clotting disorders (Thromboembolic disease in the past, elongated PT and PTT, hypercoagulability),
- •Kidney or liver failure
- •Another situation prostate resection , pathologic fractures according to anamnesis or by imaging
- •Oncology patients
- •Patients on anticoagulation
Arms & Interventions
Tranexamic Acid (TXA) treatment
Tranexamic Acid (TXA) treatment
Intervention: Tranexamic Acid (TXA) treatment (Drug)
Outcomes
Primary Outcomes
Evaluation of blood loss in ml.
Time Frame: up to 13 months
Hbloss=BV X (Hbi - Hbe) X 0.001 + Hbt Hbi - hemoglobin level before the surgery ) gram X liter-1(. Hbe - hemoglobin level 3 days after the surgery ( gram X liter-1). Hbt - The amount of hemoglobin that was given in the blood transfusion (gram). Hbloss - Change of hemoglobin loss. After calculating the amount of loss of hemoglobin, the volume of blood lost can be found: Blood loss = 1000 X Hbloss/ Hbi Evaluation of blood loss will be through: 1. Comparing hemoglobin level before and after surgery and calculation of quantitative Change of hemoglobin loss. 2 .Registration evaluating blood loss at the end of surgery 3. Collecting and recording blood drain. 4. Tracking Blood Transfusion. Of course we collect the data: assessment of bleeding in the analysis, the number of blood units given, the amount of blood collected drain
Secondary Outcomes
No secondary outcomes reported