The Use of Tranexamic Acid (TXA) Intravenously, to Reduce Blood Loss in Proximal Femur Surgery
- Conditions
- Femur Surgery
- Interventions
- Drug: Tranexamic Acid (TXA) treatment
- Registration Number
- NCT02164565
- Lead Sponsor
- HaEmek Medical Center, Israel
- Brief Summary
The use of Tranexamic Acid (TXA) intravenously, to Reduce Blood Loss in proximal femur surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
- Patients over 60, who came to the orthopedic department for proximal femur fracture surgery
- Sound judgment
- Known hypersensitivity to Tranexamic Acid or component solution provided
- Subarachnoid hemorrhage
- Acquired color blindness
- Myocardial infarction in 12 months before admission
- Unstable angina
- Known clotting disorders (Thromboembolic disease in the past, elongated PT and PTT, hypercoagulability),
- Kidney or liver failure
- Another situation prostate resection , pathologic fractures according to anamnesis or by imaging
- Oncology patients
- Patients on anticoagulation
- Patients undergoing vascular intervention ( coronary or peripheral ), which was inserted Supporter requires a Dual antiplatelet therapy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Tranexamic Acid (TXA) treatment Tranexamic Acid (TXA) treatment Tranexamic Acid (TXA) treatment
- Primary Outcome Measures
Name Time Method Evaluation of blood loss in ml. up to 13 months Hbloss=BV X (Hbi - Hbe) X 0.001 + Hbt Hbi - hemoglobin level before the surgery ) gram X liter-1(. Hbe - hemoglobin level 3 days after the surgery ( gram X liter-1). Hbt - The amount of hemoglobin that was given in the blood transfusion (gram). Hbloss - Change of hemoglobin loss.
After calculating the amount of loss of hemoglobin, the volume of blood lost can be found:
Blood loss = 1000 X Hbloss/ Hbi
Evaluation of blood loss will be through:
1. Comparing hemoglobin level before and after surgery and calculation of quantitative Change of hemoglobin loss.
2 .Registration evaluating blood loss at the end of surgery 3. Collecting and recording blood drain. 4. Tracking Blood Transfusion. Of course we collect the data: assessment of bleeding in the analysis, the number of blood units given, the amount of blood collected drain
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Orthopedic Department, HaEmek Medical Center
🇮🇱Afula, Israel