The Link Between Periodontitis, Smoking and Oral Cancer

Not yet recruiting

• Conditions: Oral Cancer; Chronic Periodontitis
• Interventions: Diagnostic Test: biopsy for oral cancer; Diagnostic Test: periodontal examination

• Registration Number: NCT04047212
• Lead Sponsor: Cairo University

Brief Summary

Periodontitis is a widely prevalent disease worldwide that has serious public health consequences. Its prognosis includes tooth loss and edentulism, a condition that negatively affects chewing causing functional disability; and esthetics causing social impairment. Consequently, periodontitis may end up causing marked impairment of the quality of life of the affected patients, impairment of general health and increasing the dental care costs significantly.

Changes in the oral mucosa arise by primary products resulting from tissue breakdown due to gingivitis. It then triggers the host cells to produce proteinases that mediate loss of marginal periodontal ligaments, apical migration of the junctional epithelium and apical spread of bacterial biofilm.

Therefore, this research aims to identify the risk of smoking to both periodontitis and oral cancer, and the risk of periodontitis to oral cancer.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-08-03
• Study First Submitted QC: 2019-08-03
• Study First Posted: 2019-08-06
• Status Verified: 2021-06
• Last Update Submitted: 2021-06-13
• Last Update Posted: 2021-06-16
• Study Start: 2021-08-12
• Primary Completion: 2031-10-12
• Study Completion: 2032-01-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Patients 18 years or older.

Exclusion Criteria

• Patients with any systemic diseases.
• Pregnant females.
• Handicapped and mentally retarded patients.
• Patients undergoing radiotherapy.
• Patients having oral cancer

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
non-Smokers	biopsy for oral cancer	-
non-Smokers	periodontal examination	-
Smokers	biopsy for oral cancer	-
Smokers	periodontal examination	-

Primary Outcome Measures

Name	Time	Method
Periodontitis	the 10 years of the study	arising of periodontitis or increase in the grade of an already existing case of periodontitis

Secondary Outcome Measures

Name	Time	Method
Oral cancer	the 10 years of the study	Arising of a lesion of oral cancer or a premalignant lesion

Trial Locations

Locations (1)

Cairo University; 🇪🇬 Cairo, Egypt