Analysis of the Link Between Periodontitis, Smoking and Oral Cancer: Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Periodontitis
研究概览
简要总结
Periodontitis is a widely prevalent disease worldwide that has serious public health consequences. Its prognosis includes tooth loss and edentulism, a condition that negatively affects chewing causing functional disability; and esthetics causing social impairment. Consequently, periodontitis may end up causing marked impairment of the quality of life of the affected patients, impairment of general health and increasing the dental care costs significantly.
Changes in the oral mucosa arise by primary products resulting from tissue breakdown due to gingivitis. It then triggers the host cells to produce proteinases that mediate loss of marginal periodontal ligaments, apical migration of the junctional epithelium and apical spread of bacterial biofilm.
Therefore, this research aims to identify the risk of smoking to both periodontitis and oral cancer, and the risk of periodontitis to oral cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients 18 years or older.
排除标准
- •Patients with any systemic diseases.
- •Pregnant females.
- •Handicapped and mentally retarded patients.
- •Patients undergoing radiotherapy.
- •Patients having oral cancer
结局指标
主要结局
Periodontitis
时间窗: the 10 years of the study
arising of periodontitis or increase in the grade of an already existing case of periodontitis
次要结局
- Oral cancer(the 10 years of the study)
研究者
Ayat Gamal-AbdelNaser
Principal investigator
Cairo University