Squalene for COVID-19 treatment

Phase 2

Conditions: COVID-19.
COVID-19, virus identified
U07.1

Registration Number: IRCT20200927048848N3

Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 200

Inclusion Criteria

Patient with definite COVID-19 confirmed by molecular or imaging methods in which the oxygen saturation level is less than 93% (SPO2 <93%) and requires respiratory support including oxygen therapy.
Patient with definite COVID-19 confirmed by molecular or imaging methods with hypotension (systolic pressure less than 90)
Patient with definite COVID-19 confirmed by molecular or imaging methods with Persistence of dehydration and oral intolerance after outpatient supportive care
Patient with definite COVID-19 confirmed by molecular or imaging methods who are considered as high risk patient regardless of the clinical symptoms based on the underlying disease, clinical condition, and paraclinical findings. (Uncontrolled high blood pressure, uncontrolled diabetes, obesity, etc.)

Exclusion Criteria

History of myocardial ischemia, heart failure and advanced COPD
Dissatisfaction of the patient or the patient's companion
Any mental disability that prevents effective communication
Existence of any physical disability that prevents one from performing daily activities independently. (Physical disability leads to disability before COVID-19 infection)
History of alcohol or drug abuse
Possibility of pregnancy and lactation

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Fever. Timepoint: Daily for 7days. Method of measurement: thermometer.;SPO2. Timepoint: daily for 7 days if hospitalization continued. Method of measurement: Pulse oxymeter.;Respiratory rate. Timepoint: daily for 7 days. Method of measurement: respiration in one minute.;Food tolerance. Timepoint: daily for 7 days. Method of measurement: physician judgment.

Secondary Outcome Measures