Molecular Characterization of Gliomas Using a Broad NGS Panel
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Malignant Glioma
- Sponsor
- Hellenic Cooperative Oncology Group
- Enrollment
- 32
- Primary Endpoint
- The prevalence of genetic alterations in patients with high grade glioma using a 80 gene NGS panel
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Gliomas are the most common malignant primary brain tumors with poor prognosis. The genotyping of tumors using NGS platforms enables the identification of genetic alterations that constitute diagnostic, prognostic and predictive biomarkers.Here in, we investigated the molecular profile of 32 tumor samples from 32 patients with high grade gliomas by implementing a broad 80-gene targeted NGS panel while reporting their clinicopathological characteristics and outcomes.
Investigators
Rania Romanidou
Dr Ourania Romanidou
Hellenic Cooperative Oncology Group
Eligibility Criteria
Inclusion Criteria
- •Diagnosis of high grade glioma based on tissue biopsy
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
The prevalence of genetic alterations in patients with high grade glioma using a 80 gene NGS panel
Time Frame: April 2019 - December 2021
The prevalence of genetic alterations in patients with high grade glioma using a 80 gene NGS panel