Evaluation of classical as well as present era causative factor of Vyanga w.s.r. to Melasma and its management by Manjishthadi Vati and Mukhakantikara Lepa

It is survey and interventional study

100 diagnosed cases of Vyanga (Melasma) having symptoms like bluish or blackish, painless and thin patches over the face and having age between 18 to 55 years and willing to participate in the study will be recruited for present study after taking their informed consent. Diagnosis of Vyanga will be confirmed by woods lamp examination. Pregnant or lactating mother will be excluded from the study. Routine laboratory investigation like hematological (Hb, TLC, DLC, ESR), liver function test, urine routine and macroscopic will be carried out to rule out any other pathology. On the basis of prepared closed ended questionnaire all the subject will be assessed to evaluate classical as well as present era causative factors for Vyanga (Melasma). Out of surveyed subjects who are willing to participate will be enrolled for clinical trial (32 patients will be enrolled in clinical trial) and randomly divided into two groups( 16 in each group). One group will be given Mukhakantikara Lepa (sufficient quantity)  twice a day and second group will be given Manjishthadi Vati 4 tablet (Each tablet 500mg) twice a day and Mukhakantikara lepa (suffecient quantity) twice a day for two months. Both group subject will be assessed fortnightly for MASI score. Woods lamp examination will be carried out before starting and at the completion of treatment. Trial group subject will be given detailed chart of dos and don’ts. Obtained clinical data will be statistically analyzed by paired and unpaired ‘t’ test. To obtain the magnitude of evaluated causative factors risk ratio of each Nidana will be calculated.