Microbiota Profile in Acute Coronary Syndrome

Girish Dwivedi0 sites200 target enrollmentStarted: December 9, 2019Last updated: March 10, 2020

Conditions

Trial Snapshot

No summary available.

•Men and women between the age of 40– 80 years of age presenting to FSH with acute
•coronary syndrome or chronic stable angina will be recruited for the study. Healthy family
•members of patients will be invited to take part in the study and will act as environmental
•controls and will be age matched where possible.
•The participant to present to FSH with acute coronary syndrome or chronic stable
•Healthy participants will be relatives of ACS patients and are defined as individuals
•with no clinically relevant abnormalities identified by a detailed medical history, full
•physical examination including blood pressure, heart rate, clinical lab tests from a
•fasting blood sample
•Evidence of a personally signed and dated informed consent document indicating that
•the participant has been informed of all pertinent aspects of the trial
•Willing and able to comply with study procedures, i.e. sample collection

•Participants will be excluded from the study:
•If there are circumstances that interfere with the participant’s ability to give informed
•consent (e.g. diminished understanding, or proficiency in English language and an
•interpreter unavailable)
•Participants taking probiotics, antibiotics or antivirals which may disrupt gut
•microbiota environment, current or recent <3 months.
•Major chronic disease e.g. cancer or dementia
•Healthy participants will be excluded if they have a history of major chronic disease
•(including cardiovascular disease, psychiatric illness, cancer, diabetes), BMI <18 or
•>35 kg/m2, current or recent (<12 months) smoking, current or recent (<6 months)
•significant weight loss or gain (>6% body weight), alcohol intake >280g p/week for
•men and >210g p/week for women.
•Inability to comply with study procedure

Sponsor

Girish Dwivedi