Pennington Generation Cohort

Recruiting

• Conditions: Obesity Prevention

• Registration Number: NCT06849206
• Lead Sponsor: Pennington Biomedical Research Center

Brief Summary

The Pennington Generation Cohort is an observational study comprised of Louisiana families. Families will be assessed at baseline for a variety of traits and behaviors, and then followed up over time to try to understand the role of lifestyle and the environment on the risk of developing obesity and other health outcomes.

Detailed Description

Pennington Biomedical's Greaux Healthy initiative partners with communities to grow healthier generations by expanding the access and reach of Pennington Biomedical's evidence-based practices for the prevention and treatment of childhood obesity. As part of Greaux Healthy, the Pennington Generation Cohort will help evaluate the impact of the program. A sample of up to 1,500 children and adolescents and their families will be recruited from throughout Louisiana. An initial physical exam will establish a baseline for each family with respect to lifestyle behaviors, genetics, and body size/composition. This longitudinal cohort will also assess the association between participation in several childhood obesity prevention and treatment programs and subsequent obesity and related health outcomes. Members of the longitudinal cohort will be followed in the future through clinical visits, questionnaires, and through optional linkages to electronic medical records and administrative databases such as the National Death Index, Social Security Death Master File, and health registry data.

Study Timeline

• Study First Submitted: 2025-02-19
• Study Start: 2025-02-24
• Study First Submitted QC: 2025-02-24
• Study First Posted: 2025-02-27
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-13
• Last Update Posted: 2025-03-17
• Primary Completion: 2045-02-24
• Study Completion: 2045-02-24

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 3000

Inclusion Criteria

• Children, adolescents, and young adults (birth through age 24 years) and their nuclear family members* and adults age 25+ who are expectant parents or are trying to conceive
• Self-reported resident of Louisiana
• Ability to understand instructions and complete all study procedures
• Able to provide informed consent (adults aged over 18 years)
• Able to provide assent (children 9 to 17 years)
• Able to communicate (oral and written) in English

Exclusion Criteria

• Discretion of the Medical Monitor or Principal Investigator

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Obesity	From enrollment up to 20 years of follow-up.	The development of obesity, defined using BMI z-scores during childhood, and BMI during adulthood.

Secondary Outcome Measures

Name	Time	Method
Weight change	From enrollment up to 20 years of follow-up.	Change in body weight.
Mortality	From enrollment up to 20 years of follow-up..	Data from the Pennington Generation Prospective Cohort will be prospectively linked to the National Death Index for the ascertainment of mortality.
Cancer incidence	From enrollment up to 20 years of follow-up..	Data from the Pennington Generation Prospective Cohort will be prospectively linked to the Louisiana Tumor Registry for the ascertainment of incident cancer.

Trial Locations

Locations (1)

Pennington Biomedical Research Center; 🇺🇸 Baton Rouge, Louisiana, United States