Rapid Diagnosis of Severe Respiratory Tract Infectious Diseases and Screening of Biomarkers for Stratified Diagnosis

Not yet recruiting

• Conditions: Biomarkers; Severe Pneumonia

• Registration Number: NCT06533514
• Lead Sponsor: Chinese PLA General Hospital

Brief Summary

The purpose of this study is to clarify the biomarkers for rapid diagnosis and stratified diagnosis of severe respiratory tract infectious diseases through clinical experiments.

Detailed Description

Methods: The relationship between relevant biomarkers and stratified diagnosis was analyzed by collecting laboratory and etiological examinations of patients with severe pneumonia.

Study Timeline

• Status Verified: 2024-07
• Study First Submitted: 2024-07-23
• Study First Submitted QC: 2024-07-30
• Last Update Submitted: 2024-07-30
• Study First Posted: 2024-08-01
• Last Update Posted: 2024-08-01
• Study Start: 2024-09-01
• Primary Completion: 2025-09-01
• Study Completion: 2025-12-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Meets the diagnostic criteria for severe pneumonia；
• Age≥18 years old and < 80 years old；
• Willing to sign informed consent for the course of the study；

Exclusion Criteria

• Patients with intracranial hypertension, acute coronary syndrome, pleural fistula, pneumothorax, or subcutaneous emphysema;
• Pregnant and lactating patients;
• Severely hemodynamically unstable (an increase in vasopressors by more than 30% in the first 6 hours, or norepinephrine >0.5mg/kg/min);
• Those who do not consent to participate in this study；

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The relationship between the patient's specific biomarker levels and clinical outcomes.	1 mounth	Treatment failure rate, Mortality rates, SOFA rating scale