LUS in Acute Heart Failure Therapeutic Adaptation

• Conditions: Acute Heart Failure; Pulmonary Congestion
• Interventions: Other: Lung ultrasound

• Registration Number: NCT04633629
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

Evaluate lung ultrasound aspect according to diuretics dosage evolution in patients hospitalized for acute heart failure.

Detailed Description

EPPICA is an observational and prospective cohort study. The study goal is to evaluate LUS aspect evolution according to diuretics dosage in patients hospitalized for acute heart failure.

Study Timeline

• Study First Submitted: 2020-09-08
• Status Verified: 2020-11
• Study First Submitted QC: 2020-11-12
• Last Update Submitted: 2020-11-12
• Study First Posted: 2020-11-18
• Last Update Posted: 2020-11-18
• Study Start: 2020-12
• Primary Completion: 2021-05
• Study Completion: 2021-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 94

Inclusion Criteria

• Acute heart failure diagnosed by a senior physician in the medical department, with a confirmation of a second senior physician.
• Hospitalised in the medical department.
• No objection from the patient of his trusted person.

Exclusion Criteria

• Administrative supervision or deprived of their liberty
• Pulmonary conditions distracting lung ultrasound (pneumonectomy, pulmonary fibrosis)
• Chronically dialysed

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with acute heart failure	Lung ultrasound	Patients hospitalized for acute heart failure in medical department.

Primary Outcome Measures

Name	Time	Method
Lung ultrasound aspect according to diuretics dosage evolution.	LUS will be performed daily during the whole hospitalisation length (on average 7 days).	B-lines number on LUS

Secondary Outcome Measures

Name	Time	Method
Lung ultrasound aspect according to clinical signs of acute heart failure (crackling auscultation or lower limbs edema)	LUS and clinical examination will be performed daily during the whole hospitalisation length (on average 7 days).	B-lines number on LUS
Lung ultrasound aspect according to early prognosis (re-hospitalisation or mortality within 30 days after discharge)	LUS will be performed daily during the whole hospitalisation length (on average 7 days). Patient will be called 30 days after discharge.	B-lines number on LUS
Lung ultrasound aspect according to acute kidney injury (based on plasmatic creatinine levels).	LUS will be performed daily during the whole hospitalisation length (on average 7 days). Plasmatic creatinine measure will be performed at least weekly.	B-lines number on LUS
Feasibility of daily LUS in medical department.	LUS will be performed daily during the whole hospitalisation length (on average 7 days).	Number of LUS performed compared to number of hospitalisation days.
Interest of LUS compared to clinical examination at discharge.	LUS and clinical examination will be performed daily during the whole hospitalisation length (on average 7 days).	B-lines at discharge compared to clinical signs of acute heart failure.