Malnutrition Assessed Through Bioelectrical Impedance Vector Analysis is Related to Poor Prognosis in Cirrhosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- Hepatic encephalopathy
研究概览
简要总结
Protein-energy malnutrition and muscle wasting are a common finding among patients with liver cirrhosis. Its prevalence may range from 50-90% depending on the methods used for nutritional assessment. Even stable cirrhotic patients referred as Child A have muscle depletion and the majority of patients classified as Child C have significant depletion. Malnutrition has been shown to be related to several complications of cirrhosis
Despite the importance of nutritional status in patient's outcome, there is no gold standard for nutritional assessment. Traditional techniques used in healthy subjects to assess nutritional status cannot be used in cirrhotic patients due especially to ascites and peripheral edema, and altered rates of biochemical markers due to liver failure.
Bioelectrical impedance vector analysis has emerged as a useful method to assess body composition and nutritional status especially in patients at the extremes of body weight (fluid overload, excess of adipose tissue, etc.).
The aim of this study is to evaluate whether malnutrition assessed by bioelectrical impedance vector analysis is related to the development of hepatic encephalopathy
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnose of cirrhosis.
- •Ambulatory patients
排除标准
- •Personal history of surgery in the last four weeks
- •Thyroid disorders without replacement therapy
- •Pregnancy
- •Active alcoholism with alcohol ingest in the previous 6 months.
- •Acute or chronic renal failure
- •Hepatic or renal transplant
结局指标
主要结局
Hepatic encephalopathy
时间窗: 6, 12, 24, 36 and 48 months
Assessed by west Haven criteria
次要结局
- Ascites(6, 12, 24, 36 and 48 months)
研究者
ALDO TORRE DELGADILLO
M.D. M.Sc
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
