Effects of Lutein Supplementation on Oxidative Stress and Inflammation in Healthy Nonsmokers
试验速览
- 阶段
- 1 期
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Biomarkers of lipid, protein and DNA oxidative damage, marker of antioxidant capacity and antioxidant enzyme activities(GPx,SOD and CAT)in healthy subjects.
研究概览
简要总结
Lutein is one of oxygenated carotenoids. Over the past few years, there has been increased interest in evaluating the effect of lutein for optimizing immune functions. A large number of epidemiological studies support the notion that a high intake of lutein is associated with a reduced risk of coronary heart disease and certain types of cancer. The biological mechanisms for the protective effects of this carotenoid, including powerful modulation of functions and antioxidant properties, are only partially known. Although several nutrients and phytochemicals have been shown to modulate immune functions in humans, few studies have investigated the role of lutein consumption. No information is available as to whether lutein supplementation could be protective against oxidative stress. Therefore, the objective of the present study was to examine the effect of consuming different doses of lutein on oxidative stress in healthy subjects.
详细描述
Participants with a history of smoking, alcohol consumption, body mass index (BMI)≥30kg/m2, allergies, ocular diseases and participants taking vitamins or other food supplements containing lutein were excluded from the study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adult subjects aged in the range of 20 to 80
排除标准
- •Participants with a history of smoking
- •Alcohol consumption
- •Body mass index (BMI)≥30kg/m2
- •Allergies
- •Ocular diseases or recent infections(within the last year) and participants taking vitamins or other food supplements containing lutein the previous 2 months.
研究组 & 干预措施
20mg Lutein
Dietary Supplement: 20mg Lutein; daily supplementation 12 week
干预措施: Lutein (Drug)
10mg Lutein
Dietary Supplement: 10mg Lutein; daily supplementation 12 week
干预措施: Lutein (Drug)
0mg Lutein
Dietary Supplement: 0mg Lutein; daily supplementation 12 week
干预措施: Lutein (Drug)
结局指标
主要结局
Biomarkers of lipid, protein and DNA oxidative damage, marker of antioxidant capacity and antioxidant enzyme activities(GPx,SOD and CAT)in healthy subjects.
时间窗: 12 weeks
次要结局
未报告次要终点
研究者
Le MA
Xi'an Jiaotong University College of Medicine
Health Science Center of Xi'an Jiaotong University