Seek, Test, Treat Strategies for Vietnamese Drug Users: A Randomized Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- HIV
- Sponsor
- Johns Hopkins University
- Enrollment
- 378
- Locations
- 1
- Primary Endpoint
- Time from randomization to the initiation of antiretroviral therapy (ART)
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
This research examines the effectiveness of an intervention that employs seek, test, and treat strategies for Vietnamese injection drug users (IDU) and their network members, by ensuring that high risk individuals are sought for HIV testing and promptly referred to and maintained on antiretroviral therapy (ART). HIV prevention interventions are provided to IDUs who test HIV-negative, as well as those who test HIV-positive. HIV-positive IDUs will be referred to HIV care through a two-arm randomized controlled trial to compare the effects of different levels of engagement in care on ART uptake, ART adherence, and treatment outcome.
Detailed Description
Opioid injection and HIV infection are major public health problems in Vietnam. Injection drug users (IDUs) have a high burden of HIV infection (20% HIV prevalence, nationally; 6% mortality per year) and the high rate of HIV transmission continues (HIV incidence, 5% per year). The investigators propose an intervention that employs the seek, test, and treat strategies for the IDU population and their network members, by ensuring that high risk individuals are sought for HIV testing, promptly referred to and maintained on ART, while HIV prevention interventions provided to the many who test HIV-negative, as well as those who test HIV-positive. The intervention will seek and test IDUs and their network members in the community, particularly those who are recently released from drug treatment centers. HIV-positive IDUs will be referred to HIV care through a two arm randomized controlled trial to compare the effects of different levels of engagement in care on ART uptake, antiretroviral adherence, and treatment outcome.
Investigators
Vu Minh Quan
Assistant Professor
Johns Hopkins University
Eligibility Criteria
Inclusion Criteria
- •Age 18 years or older;
- •Recently released from drug treatment centers;
- •Positive HIV serology;
- •Meet criteria for ART initiation according to Vietnam's national guidelines;
- •Provide informed consent for the study; and
- •Reside in study area and do not plan to move away in the next 18 months.
Exclusion Criteria
- •Currently on ART;
- •Co-enrollment in other HIV interventional research study;
- •Unwilling to provide locator information.
Outcomes
Primary Outcomes
Time from randomization to the initiation of antiretroviral therapy (ART)
Time Frame: At month 3
Secondary Outcomes
- HIV-1 RNA levels(At months 6 and 12)
- CD4+ counts(At months 6, 12, and 18)