Comparative Study of Recovery Characteristics Between Remimazolam Anesthesia With Flumazenil and Desflurane Anesthesia for Closed Reduction of Nasal Bone Fracture
Overview
- Phase
- Not Applicable
- Intervention
- Remimazolam
- Conditions
- Anesthesia
- Sponsor
- Daegu Catholic University Medical Center
- Enrollment
- 58
- Locations
- 1
- Primary Endpoint
- Time to follow verbal command
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The goal of this prospective, randomized study is to compare recovery characteristics between remimazolam anesthesia with flumazenil and desflurane anesthesia in patients undergoing closed reduction of nasal bone fracture. The main question this study aims to answer is:
- Is there statistically significant difference in time from discontinuation of the anesthetic agent up to patient's response to verbal command between these two groups?
Participants will receive either remimazolam or desflurane for the maintenance of general anesthesia. When the surgery ends, the anesthetic agent will be stopped. For Remimazolam group, flumazenil will be administered as an antagonist of remimazolam.
Investigators
SO YOUNG LEE
Assistant professor
Daegu Catholic University Medical Center
Eligibility Criteria
Inclusion Criteria
- •Age between 19 and 75 years
- •American Society of Anesthesiologists physical status (ASA PS) of I-II
- •Patients undergoing elective closed reduction of nasal bone fracture
Exclusion Criteria
- •Patient who cannot understand the process of this study
- •Cognitive, visual or hearing impairment
- •Chronic use of antipsychotic medications or medications for sleeping problem
- •Use of benzodiazepine
- •Patient with kidney or liver disease
- •Body mass index (BMI) \>30 kg/m\^2
Arms & Interventions
Remimazolam group
receives remimazolam for the maintenance of general anesthesia. At the end of surgery, flumazenil is administered as an antagonist of remimazolam.
Intervention: Remimazolam
Desflurane group
receives desflurane for the maintenance of general anesthesia.
Intervention: Desflurane
Outcomes
Primary Outcomes
Time to follow verbal command
Time Frame: from discontinuation of anesthetic agent to response to a verbal command of moving participant's foot, up to 30 minutes
Time between discontinuation of anesthetic agent and response to a verbal command of moving participant's foot
Secondary Outcomes
- time to eye opening(from discontinuation of anesthetic agent to eye opening, up to 30 minutes)
- Incidence of agitation during emergence period(from discontinuation of anesthetic agent to 2 minutes after extubation)
- Mean arterial blood pressure(from 5 minutes before anesthesia induction to end of anesthesia)
- time to extubation(form discontinuation of anesthetic agent to extubation, up to 30 minutes)