Causes, Characteristics and Treatment of Hypercalcemia in the Emergency Room of a German Hospital

Active, not recruiting

• Conditions: Hypercalcemia

• Registration Number: NCT06467877
• Lead Sponsor: University of Cologne

Brief Summary

Patients with hypercalcemia were identified in the patient population of a German emergency department during a 11 year time period and studied regarding reproducibility of elevated calcium values, causes of hypercalcemia, symptoms. acute renal injury, mortality and treatment response.

Detailed Description

Patients, who presented to the emergency department of a tertiary German hospital with a total calcium of ≥2.65 mmol/l between January 2010 and March 2021, was retrospectively studied. From the electronic patient records we analyzed if the elevated calcium values were reproducible in follow-up measurements, identified the cause of hypercalcemia, listed the symptoms, investigated a correlation between calcium and creatinine values to study acute renal injury directly due to hypercalcemia, calculated the mortality rate stratified by the calcium value on presentation and studied the treatment response regarding lowering calcium values by different treatments.

Study Timeline

• Study Start: 2010-01-01
• Primary Completion: 2021-03-31
• Study First Submitted: 2024-06-14
• Study First Submitted QC: 2024-06-20
• Study First Posted: 2024-06-21
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-04
• Last Update Posted: 2024-12-09
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Age > 18 years
• Total calcium ≥ 2.65 mmol/l
• Female and male

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Exclusion Criteria

• Age < 18 years
• Total calcium < 2.65 mmol/

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Development of total calcium values	5 days after enrollment	Overview of total calcium values within 5 days

Secondary Outcome Measures

Name	Time	Method
Reproducibility of elevated calcium values	5 days after enrollment	Determination of cause of hypercalcemia, of symptoms, of treatment response. In dependence of hospital stay, kann be determined later than 5 days after enrollment
Correlation creatinine calcium	5 days after enrollment	Determination of correlation between calcium and creatinine.
Mortality	5 days after enrollment	occurence of death within of 5 days after enrollment

Trial Locations

Locations (1)

Department II of Internal Medicine,University of Cologne; 🇩🇪 Cologne, Germany