NCT06312345Unknown不适用
Ciprofol Versus Propofol for Anesthesia Induction in Cardiac Surgery: A Randomized Double-blind Controlled Clinical Trial
Le Yu1 个研究点 分布在 1 个国家目标入组 80 人开始时间: 2024年3月11日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Heart beats
研究概览
简要总结
Ciprofol, a novel intravenous general anesthetic with a chemical structure akin to propofol, boasts significantly enhanced potency. It offers a rapid onset, reduced incidence of injection pain, and minor impact on the cardiovascular system. However, clinical research regarding ciprofol's use for anesthesia induction in cardiac surgery remains limited.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 55 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Elective surgery patients
- •Aged 55 to 75
- •New York Heart Association class II or III cardiac functions
- •Median sternotomy approach for coronary artery bypass grafting or heart valve replacement procedures
排除标准
- •With a history of benzodiazepine allergy
- •Significant liver or kidney insufficiency
- •Coagulation dysfunction
- •Neurological or psychiatric disorders
- •Undergone major surgery within the past three months.
结局指标
主要结局
Heart beats
时间窗: 5 minutes after tracheal intubation (T4)
the number of times each minute that heart beats
Mean arterial pressure
时间窗: 5 minutes after tracheal intubation (T4)
an average blood pressure in an individual during a single cardiac cycle
次要结局
- Injection pain(During procedure (When injecting the drug, ask the subject if the injection site is painful))
- Oxygenation index(10 minutes after tracheal intubation (T5))
研究者
Le Yu
Clinicians
Shanghai East Hospital of Tongji University
研究点 (1)
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