Cranberry (Poly)Phenol Consumption on Vascular Function

Not Applicable

Completed

• Conditions: Healthy Young
• Interventions: Dietary Supplement: cranberry (poly)phenol containing supplement

• Registration Number: NCT02764749
• Lead Sponsor: Heinrich-Heine University, Duesseldorf

Brief Summary

Epidemiological studies suggest that the consumption of (poly)phenols rich foods such as cocoa, tea, fruits and vegetables is associated with lower blood pressure, reduced cholesterol and decreased cardiovascular risk. Cranberries are a rich source of (poly)phenols, including anthocyanins, proanthocyanidins and phenolic acids. Whether cranberries can improve vascular function when given over relevant time periods and in relevant populations is not known. Therefore, it is the overall hypothesis of the study proposal that chronic consumption of cranberries can improve endothelial function, a prognostically validated surrogate of cardiovascular risk. This study also aims to reveal which cranberry (poly)phenols have bioactive properties in healthy men. Consequently, plasma and urine metabolite peaks will be correlated with vascular outcomes and genome-wide expression microarrays will be performed to reveal cell signaling pathways associated with cranberry (poly)phenol-mediated cardioprotective events.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-05-04
• Study First Submitted QC: 2016-05-05
• Study First Posted: 2016-05-06
• Study Start: 2016-06
• Primary Completion: 2016-10
• Study Completion: 2016-10
• Status Verified: 2016-11
• Last Update Submitted: 2016-11-24
• Last Update Posted: 2016-11-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 40

Inclusion Criteria

• healthy male subjects (no clinical signs or symptoms of CVD)
• Young >18 years, <35 years

Exclusion Criteria

• CVD
• acute inflammation
• cardiac arrhythmia
• renal failure
• heart failure (NYHA II-IV)
• diabetes mellitus
• CRP > 1 mg/dl
• malignant disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
freeze dried powder whole cranberry dissolved in water	cranberry (poly)phenol containing supplement	Dietary Supplement: freeze dried cranberry powder

Primary Outcome Measures

Name	Time	Method
Change form Baseline Endothelial function at 1 month	2 hours and 1 month	Measured by Flow mediated dilation (FMD)

Secondary Outcome Measures

Name	Time	Method
Pulse wave velocity	Baseline and 1 month	Measured by SphygmoCor 0 and 2 hours postconsumption
Blood pressure	Baseline and 1month	automatical measurements 0 and 2 hours postconsumption
high density lipoproteins (HDL)	Baseline and 1 month	measured on baseline and after 1 month
low density lipoproteins (LDL)	Baseline and 1 month	measured on baseline and after 1 month
triglyceride	Baseline and 1 month	measured on baseline and after 1 month

Trial Locations

Locations (1)

Division of Cardiology, Pulmonary Disease and Vascular Medicine, University Hospital Duesseldorf; 🇩🇪 Duesseldorf, Germany