MedPath

A Study of Selpercatinib After Surgery or Radiation in Participants With Non-Small Cell Lung Cancer (NSCLC)

Phase 3
Active, not recruiting
Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
Drug: Placebo
Registration Number
NCT04819100
Lead Sponsor
Eli Lilly and Company
Brief Summary

The reason for this study is to see if the study drug, selpercatinib, compared to placebo is effective and safe in delaying cancer return in participants with early-stage non-small cell lung cancer (NSCLC), who have already had surgery or radiation. Participants who are assigned to placebo and stop the study drug because their disease comes back or gets worse have the option to potentially crossover to selpercatinib. Participation could last up to three years.

Detailed Description

Not available

Recruitment & Eligibility

Status
ACTIVE_NOT_RECRUITING
Sex
All
Target Recruitment
152
Inclusion Criteria
  • Must have histologically confirmed Stage IB, II, or IIIA NSCLC.

  • Must have an activating RET gene fusion in tumor based on polymerase chain reaction (PCR), next generation sequencing (NGS), or another molecular test per sponsor's approval.

  • Must have received definitive locoregional therapy with curative intent (surgery or radiotherapy) for Stage IB, II, or IIIA NSCLC.

    -- Must have undergone the available anti-cancer therapy (including chemotherapy or durvalumab) or not be suitable for it, based on the investigator's discretion.

  • Maximum time allowed between definitive therapy completion and randomization must be:

    • 10 weeks if no chemotherapy was administered
    • 26 weeks if adjuvant chemotherapy was administered
  • Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.

  • Adequate hematologic, hepatic, and renal function.

  • Willingness of men and women of reproductive potential to observe conventional and highly effective birth control for the duration of the study and for at least 2 weeks after last dose of study drug.

Exclusion Criteria
  • Additional oncogenic drivers in NSCLC, if known.
  • Evidence of small cell lung cancer.
  • Clinical or radiologic evidence of disease recurrence or progression following definitive therapy.
  • Known or suspected interstitial fibrosis or interstitial lung disease or history of (noninfectious) pneumonitis that required steroids.
  • Clinically significant active cardiovascular disease or history of myocardial infarction within six months prior to planned start of selpercatinib or prolongation of the QT interval corrected for heart rate using Fridericia's formula (QTcF) greater than 470 milliseconds.
  • Have known uncontrolled human immunodeficiency virus (HIV)-1/2 infection.
  • Have known active hepatitis B or C.
  • Active uncontrolled systemic bacterial, viral, or fungal infection or serious ongoing intercurrent illness, such as hypertension or diabetes, despite optimal treatment.
  • Major surgery within 4 weeks prior to planned start of selpercatinib.
  • Clinically significant active malabsorption syndrome or other condition likely to affect gastrointestinal absorption of the study drug.
  • Other malignancy unless nonmelanoma skin cancer, carcinoma in situ of the cervix or other in situ cancers or a malignancy diagnosed greater than or equal to two years previously and not currently active.
  • Pregnancy or lactation.
  • Prior treatment with a selective RET inhibitor (e.g. selpercatinib or pralsetinib).

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
SelpercatinibSelpercatinibSelpercatinib administered orally.
PlaceboPlaceboPlacebo administered orally.
Primary Outcome Measures
NameTimeMethod
Event-Free Survival (EFS)Randomization to disease recurrence/progression or death from any cause (estimated as up to 7 years)

EFS by Investigator Assessment in the Primary Analysis Population

Secondary Outcome Measures
NameTimeMethod
Overall Survival (OS)Randomization to death from any cause (estimated as up to 9 years)]

OS

Mean Change from Baseline over Time in NSCLC SymptomsBaseline to treatment discontinuation (estimated as up to 3 years)

NSCLC symptoms will be measured using the 7-item NSCLC Symptom Assessment Questionnaire (NSCLC-SAQ). The NSCLC-SAQ measures the severity/frequency of the following core symptoms: Cough, pain, dyspnea, fatigue, and appetite. Raw scores range from 0 to 4 and the total score ranges from 0-20. Higher scores represent worse symptoms.

Mean Change from Baseline over Time in Physical FunctionBaseline to treatment discontinuation (estimated as up to 3 years)

Physical function will be measured by the 5 physical function items in the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC-QLQ-C30) (also known as the EORTC IL 19 questionnaire). Raw scores range from 0-20. Higher scores indicate worst function.

EFSRandomization to disease recurrence/progression or death from any cause (estimated as up to 7 years)]

EFS by blinded independent central review (BICR)

Time to Distant Disease Recurrence in the Central Nervous System (CNS)Randomization to disease recurrence/progression or death from any cause (estimated as up to 7 years)

Time to distant disease recurrence in the CNS by investigator assessment and BICR

Positive Predictive Value (PPV) of Rearranged during Transfection (RET) Tests from Investigator-Identified Laboratories with Respect to the Lilly-Designated RET TestBaseline

PPV of RET Tests from Investigator-Identified Laboratories with Respect to the Lilly-Designated RET Test

Progression Free Survival on the Next Line of Treatment (PFS2)Randomization to disease progression on the next line of treatment or death from any cause (estimated as up to 9 years)

PFS2 by investigator assessment

Trial Locations

Locations (211)

Acıbadem Maslak Hastanesi

🇹🇷

İstanbul, Turkey

Klinikum der Ludwig-Maximilians-Universitaet Muenchen

🇩🇪

München, Bayern, Germany

Border Medical Oncology

🇦🇺

Wodonga, Victoria, Australia

UCLA Hematology/Oncology - Santa Monica

🇺🇸

Los Angeles, California, United States

Stockton Hematology Oncology Group

🇺🇸

Stockton, California, United States

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

🇺🇸

Torrance, California, United States

GenesisCare

🇺🇸

Aventura, Florida, United States

GenesisCare - Boca Raton

🇺🇸

Boca Raton, Florida, United States

USO-Cancer Care Center of Brevard, Inc.

🇺🇸

Palm Bay, Florida, United States

Dana-Farber Cancer Institute

🇺🇸

Boston, Massachusetts, United States

Mayo Clinic in Rochester, Minnesota

🇺🇸

Rochester, Minnesota, United States

USO-New York Oncology Hematology, P.C

🇺🇸

Latham, New York, United States

Memorial Sloan Kettering Cancer Center

🇺🇸

New York, New York, United States

USO - Alliance Cancer Specialists, PC

🇺🇸

Horsham, Pennsylvania, United States

Sarah Cannon Research Institute SCRI

🇺🇸

Nashville, Tennessee, United States

Tennessee Oncology Nashville

🇺🇸

Nashville, Tennessee, United States

USO-Texas Oncology-Central/South Texas

🇺🇸

Austin, Texas, United States

US Oncology

🇺🇸

The Woodlands, Texas, United States

Sunshine Coast University Hospital

🇦🇺

Birtinya, Queensland, Australia

Rockhampton Hospital

🇦🇺

Rockhampton, Queensland, Australia

The Townsville Hospital

🇦🇺

Townsville, Queensland, Australia

Ballarat Health Services

🇦🇺

Ballarat Central, Victoria, Australia

Bendigo Health Care Group

🇦🇺

Bendigo, Victoria, Australia

Goulburn Valley Health

🇦🇺

Shepparton, Victoria, Australia

South West Healthcare

🇦🇺

Warrnambool, Victoria, Australia

Landeskrankenhaus Feldkirch

🇦🇹

Feldkirch, Vorarlberg, Austria

Klinik Floridsdorf

🇦🇹

Wien, Austria

Antwerp University Hospital

🇧🇪

Edegem, Antwerpen, Belgium

Cliniques universitaires Saint-Luc

🇧🇪

Brussels, Bruxelles-Capitale, Région De, Belgium

Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godinne

🇧🇪

Yvoir, Namur, Belgium

Clinique Saint Pierre

🇧🇪

Ottignies, Wallonne, Région, Belgium

AZ Delta vzw

🇧🇪

Roeselare, West-Vlaanderen, Belgium

CHU UCL Namur/Site Sainte Elisabeth

🇧🇪

Namur, Belgium

Nucleo de Oncologia da Bahia

🇧🇷

Salvador, Bahia, Brazil

Sirio-Libanes Brasilia - Centro de Oncologia - Asa Sul

🇧🇷

Brasilia, Distrito Federal, Brazil

Oncocentro de Minas Gerais

🇧🇷

Belo Horizonte, Minas Gerais, Brazil

Centro Oncológico do Triângulo

🇧🇷

Uberlândia, Minas Gerais, Brazil

Multihemo

🇧🇷

Recife, Pernambuco, Brazil

Hospital São Lucas da PUCRS

🇧🇷

Porto Alegre, Rio Grande Do Sul, Brazil

Hospital BP

🇧🇷

Sao Paulo, São Paulo, Brazil

Instituto D'Or de Pesquisa e Ensino (IDOR)

🇧🇷

Sao Paulo, São Paulo, Brazil

Instituto de Educação, Pesquisa e Gestão em Saúde

🇧🇷

Rio de Janeiro, Brazil

Centro Paulista de Oncologia Clínica

🇧🇷

São Paulo, Brazil

Núcleo de Pesquisa Clínica da Rede São Camilo

🇧🇷

São Paulo, Brazil

Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein

🇧🇷

São Paulo, Brazil

Princess Margaret Cancer Centre

🇨🇦

Toronto, Ontario, Canada

Beijing Friendship Hospital

🇨🇳

Beijing, Beijing, China

Beijing Cancer hospital

🇨🇳

Beijing, Beijing, China

Fujian Provincial Hospital

🇨🇳

Fuzhou, Fujian, China

Southern Medical University Nanfang Hospital

🇨🇳

Guangzhou, Guangdong, China

Guangdong Provincial People's Hospital

🇨🇳

Guangzhou, Guangdong, China

Harbin Medical University Cancer Hospital

🇨🇳

Harbin, Heilongjiang, China

Xiangya Hospital, Central South University

🇨🇳

Changsha, Hunan, China

Hunan Cancer Hospital

🇨🇳

Changsha, Hunan, China

Jilin Cancer Hospital

🇨🇳

Changchun, Jilin, China

Tangdu Hospital of Fourth Military Medical University of Chinese People's Liberation Army

🇨🇳

Xi'an, Shaanxi, China

Jinan Central Hospital

🇨🇳

Jinan, Shandong, China

Shanghai Chest Hospital

🇨🇳

Shanghai, Shanghai, China

Zhongshan Hospital, Fudan University

🇨🇳

Shanghai, Shanghai, China

Shanghai Pulmonary Hospital

🇨🇳

Shanghai, Shanghai, China

West China Hospital, Sichuan University

🇨🇳

Cheng Du, Sichuan, China

the Third People's Hospital of Chengdu

🇨🇳

Chengdu, Sichuan, China

First Affiliated Hosp of College of Med, Zhejiang University

🇨🇳

Hangzhou, Zhejiang, China

Zhejiang Cancer Hospital

🇨🇳

Hangzhou, Zhejiang, China

Tongji Medical College of Huazhong University of Science and Technology

🇨🇳

Wuhan, China

Masarykuv onkologicky ustav

🇨🇿

Brno, Brno-město, Czechia

Nemocnice AGEL Ostrava - Vitkovice a.s.

🇨🇿

Ostrava, Ostrava Město, Czechia

Fakultni nemocnice Bulovka

🇨🇿

Prague, Praha 8, Czechia

Odense Universitetshospital

🇩🇰

Odense, Syddanmark, Denmark

Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone

🇫🇷

Marseille, Bouches-du-Rhône, France

CHU Charles Nicolle

🇫🇷

Rouen, Haute-Normandie, France

Centre Chirurgical Marie Lannelongue

🇫🇷

Le Plessis-Robinson, Hauts-de-Seine, France

Centre Leon Berard

🇫🇷

Lyon CEDEX 08, Rhône-Alpes, France

Hospices Civils de Lyon - Hopital Louis Pradel

🇫🇷

Lyon, Rhône, France

Gustave Roussy

🇫🇷

Villejuif, Val-de-Marne, France

Hopitaux Universitaires Paris Centre-Hopital Cochin

🇫🇷

Paris, France

Thoraxklinik-Heidelberg gGmbH

🇩🇪

Heidelberg, Baden-Württemberg, Germany

Klinik Löwenstein

🇩🇪

Löwenstein, Baden-Württemberg, Germany

Asklepios Fachkliniken München-Gauting

🇩🇪

Gauting, Bayern, Germany

Lungenfachklinik Immenhausen

🇩🇪

Immenhausen, Hessen, Germany

Franziskus-Hospital Harderberg

🇩🇪

Georgsmarienhütte, Niedersachsen, Germany

KRH, Klinikum Siloah

🇩🇪

Hannover, Niedersachsen, Germany

Universitätsklinikum Münster - Albert Schweitzer Campus

🇩🇪

Münster, Nordrhein-Westfalen, Germany

LungenClinic Grosshansdorf

🇩🇪

Grosshansdorf, Schleswig-Holstein, Germany

Charite Universitätsmedizin Berlin Campus Benjamin Franklin

🇩🇪

Berlin, Germany

Evangelische Lungenklinik Berlin

🇩🇪

Berlin, Germany

Asklepios Klinik Harburg

🇩🇪

Hamburg, Germany

University Hospital of Patras

🇬🇷

Patras, Achaḯa, Greece

Agios Savvas Regional Cancer Hospital

🇬🇷

Athens, Attikí, Greece

Errikos Dunant Hospital Center

🇬🇷

Athens, Attikí, Greece

Sotiria Thoracic Diseases Hospital of Athens

🇬🇷

Athens, Attikí, Greece

University General Hospital of Heraklion

🇬🇷

Heraklion, Irakleío, Greece

European Interbalkan Medical Center

🇬🇷

Thessaloniki, Thessaloníki, Greece

G. Papanikolaou General Hospital

🇬🇷

Thessaloniki, Thessaloníki, Greece

Hong Kong United Oncology Centre

🇭🇰

Hong Kong, Hong Kong

Princess Margaret Hospital

🇭🇰

Lai Chi Kok, Hong Kong

Queen Elizabeth Hospital

🇭🇰

Yau Ma Tei, Hong Kong

Rajiv Gandhi Cancer Institute And Research Centre

🇮🇳

New Delhi, Delhi, India

Regional Cancer Centre - Thiruvananthapuram

🇮🇳

Thiruvananthapuram, Kerala, India

Tata Memorial Hospital

🇮🇳

Mumbai, Maharashtra, India

Rashtrasant Tukdoji Regional Cancer Hospital

🇮🇳

Nagpur, Maharashtra, India

HCG Manavata Cancer Centre

🇮🇳

Nashik, Maharashtra, India

Sheba Medical Center

🇮🇱

Ramat Gan, HaMerkaz, Israel

Hadassah Medical Center

🇮🇱

Jerusalem, Yerushalayim, Israel

Rambam Health Care Campus

🇮🇱

Haifa, Ḥeifā, Israel

ASST Grande Ospedale Metropolitano Niguarda

🇮🇹

Milan, Milano, Italy

Humanitas

🇮🇹

Rozzano, Milano, Italy

Azienda Ospedaliera Dei Colli

🇮🇹

Naples, Napoli, Italy

Instituto Tumori Giovanni Paolo II

🇮🇹

Bari, Puglia, Italy

Azienda Sanitaria Ospedaliera S Luigi Gonzaga

🇮🇹

Orbassano, Torino, Italy

Istituto Oncologico Veneto IRCCS

🇮🇹

Padova, Italy

Aichi Cancer Center Hospital

🇯🇵

Nagoya, Aichi, Japan

National Cancer Center Hospital East

🇯🇵

Kashiwa, Chiba, Japan

Himeji Medical Center

🇯🇵

Himeji, Hyogo, Japan

Kanagawa cancer center

🇯🇵

Yokohama, Kanagawa, Japan

Niigata Cancer Center Hospital

🇯🇵

Niigata-shi, Niigata, Japan

Shizuoka Cancer Center

🇯🇵

Nagaizumi, Shizuoka, Japan

Japanese Foundation for Cancer Research

🇯🇵

Koto, Tokyo, Japan

Tottori University Hospital

🇯🇵

Yonago, Tottori, Japan

Hiroshima University Hospital

🇯🇵

Hiroshima, Japan

Osaka International Cancer Institute

🇯🇵

Osaka, Japan

Chonnam National University Hwasun Hospital

🇰🇷

Hwasun, Jeonranamdo, Korea, Republic of

National Cancer Center

🇰🇷

Goyang-si, Kyǒnggi-do, Korea, Republic of

Seoul National University Bundang Hospital

🇰🇷

Seongnam, Kyǒnggi-do, Korea, Republic of

Pusan National University Hospital

🇰🇷

Busan, Pusan-Kwangyǒkshi, Korea, Republic of

Seoul National University Hospital

🇰🇷

Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Severance Hospital, Yonsei University Health System

🇰🇷

Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Asan Medical Center

🇰🇷

Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Samsung Medical Center

🇰🇷

Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Korea University Guro Hospital

🇰🇷

Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Kyungpook National University Chilgok Hospital

🇰🇷

Deagu, Taegu-Kwangyǒkshi, Korea, Republic of

Actualidad Basada en la Investigación del Cáncer

🇲🇽

Guadalajara, Jalisco, Mexico

Oncare Viaducto Napoles

🇲🇽

Cdmx, México, Mexico

Avix Investigación Clinica, S.C.

🇲🇽

Monterrey, Nuevo León, Mexico

Hospital Universitario "Dr. Jose Eleuterio Gonzalez"

🇲🇽

Monterrey, Nuevo León, Mexico

Ziekenhuis St. Jansdal

🇳🇱

Harderwijk, Gelderland, Netherlands

Radboudumc

🇳🇱

Nijmegen, Gelderland, Netherlands

Oslo Universitetssykehus Ullevål

🇳🇴

Oslo, Norway

Krakowski Szpital Specjalistyczny im. Jana Pawa II

🇵🇱

Krakow, Małopolskie, Poland

Pan American Center for Oncology Trials

🇵🇷

Rio Piedras, Puerto Rico

Institutul Oncologic

🇷🇴

Cluj, Romania

Arkhangelsk Clinical Oncological Dispensary

🇷🇺

Arkhangelsk, Arkhangel'skaya Oblast', Russian Federation

Hadassah Medical

🇷🇺

Moscow, Moskva, Russian Federation

First Pavlov State Medical University of Saint Petersburg

🇷🇺

Saint Petersburg, Sankt-Peterburg, Russian Federation

Scientific research institution of oncology named after N.N. Petrov

🇷🇺

Sankt-Peterburg, Russian Federation

Parkway Cancer Centre - Gleneagles Hospital

🇸🇬

Singapore, Central Singapore, Singapore

Tan Tock Seng Hospital

🇸🇬

Singapore, Central Singapore, Singapore

CHUS - Hospital Clinico Universitario

🇪🇸

Santiago de Compostela, A Coruña [La Coruña], Spain

Hospital Universitario Reina Sofia

🇪🇸

Cordoba, Andalucía, Spain

Hospital Universitario Puerta del Mar

🇪🇸

Cádiz, Andalucía, Spain

Hospital Universitario Central de Asturias

🇪🇸

Oviedo, Asturias, Spain

Institut Català d'Oncologia (ICO) - Badalona

🇪🇸

Badalona, Barcelona [Barcelona], Spain

Parc de Salut Mar - Hospital del Mar

🇪🇸

Barcelona, Barcelona [Barcelona], Spain

Hospital Universitari Vall d'Hebron

🇪🇸

Barcelona, Barcelona [Barcelona], Spain

Instituto Catalan de Oncologia - Hospital Duran i Reynals

🇪🇸

L'Hospitalet Del Llobregat, Barcelona [Barcelona], Spain

Hospital de Mataró

🇪🇸

Mataró, Barcelona [Barcelona], Spain

Complejo Asistencial Universitario de León - Hospital de León

🇪🇸

León, Castilla Y León, Spain

Hospital Universitari Dexeusa

🇪🇸

Barcelona, Catalunya [Cataluña], Spain

Hospital Clínic de Barcelona

🇪🇸

Barcelona, Catalunya [Cataluña], Spain

Hospital Son Llàtzer

🇪🇸

Palma, Illes Balears [Islas Baleares], Spain

Hospital Lucus Augusti

🇪🇸

Lugo, Lugo [Lugo], Spain

Hospital Universitario Ramón y Cajal

🇪🇸

Madrid, Madrid, Comunidad De, Spain

Hospital Universitario 12 de Octubre

🇪🇸

Madrid, Madrid, Comunidad De, Spain

Hospital Clínico Universitario Virgen de la Arrixaca

🇪🇸

El Palmar, Murcia, Murcia, Región De, Spain

Complexo Hospitalario Universitario de Ourense

🇪🇸

Ourense, Ourense [Orense], Spain

CHUVI- Hospital Alvaro Cunqueiro

🇪🇸

Pontevedra, Pontevedra [Pontevedra], Spain

Hospital Universitario de Canarias

🇪🇸

La Laguna, Santa Cruz De Tenerife, Spain

Hospital Universitari Sant Joan de Reus

🇪🇸

Reus, Tarragona [Tarragona], Spain

Hospital General Universitario de Albacete

🇪🇸

Albacete, Spain

Trakya University

🇹🇷

Edirne, Turkey

MD Anderson Cancer Center

🇪🇸

Madrid, Spain

Hospital Clinico San Carlos

🇪🇸

Madrid, Spain

H.R.U Málaga - Hospital General

🇪🇸

Málaga, Spain

Medipol Mega Universite Hastanesi

🇹🇷

Istanbul, Turkey

Hospital Universitario Virgen Macarena

🇪🇸

Sevilla, Spain

Hospital Universitari i Politecnic La Fe

🇪🇸

València, Spain

Sahlgrenska Universitetssjukhuset

🇸🇪

Gothenburg, Västra Götalands Län [se-14], Sweden

Changhua Christian Hospital

🇨🇳

Changhua County, Changhua, Taiwan

Chang Gung Memorial Hospital at Kaohsiung

🇨🇳

Kaohsiung Niao Sung Dist, Kaohsiung, Taiwan

Chung Shan Medical University Hospital

🇨🇳

Taichung City, Taichung, Taiwan

Chi Mei Hospital - Liouying Branch

🇨🇳

Tainan City, Tainan, Taiwan

National Taiwan University Cancer Center (NTUCC)

🇨🇳

Taipei City, Taipei, Taiwan

Taipei Veterans General Hospital

🇨🇳

Taipei City, Taipei, Taiwan

Kaohsiung Medical University Chung-Ho Memorial Hospital

🇨🇳

Kaohsiung, Taiwan

Taichung Veterans General Hospital

🇨🇳

Taichung, Taiwan

National Taiwan University Hospital

🇨🇳

Taipei, Taiwan

Chang Gung Medical Foundation-Linkou Branch

🇨🇳

Taoyuan, Taiwan

Ege Universitesi Hastanesi

🇹🇷

Bornova, İzmir, Turkey

Izmir Medical Park Hospital

🇹🇷

Izmir, Karsiyaka, İzmir, Turkey

Baskent University Dr. Turgut Noyan Research and Training Center

🇹🇷

Adana, Turkey

Adana City Hospital

🇹🇷

Adana, Turkey

Abdurrahman Yurtaslan Ankara Oncology, education and Research Hospital

🇹🇷

Ankara, Turkey

Ankara Bilkent Şehir Hastanesi

🇹🇷

Ankara, Turkey

Memorial Antalya Hospital

🇹🇷

Antalya, Turkey

Uludag Universitesi

🇹🇷

Bursa, Turkey

Dicle Üniversitesi

🇹🇷

Diyarbakir, Turkey

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi

🇹🇷

Istanbul, Turkey

Izmir Katip Celebi Ataturk Egitim Arastirma Hastanesi

🇹🇷

Izmir, Turkey

İnönü Üniversitesi Turgut Özal Tıp Merkezi Eğitim ve Araştırma Hastanesi

🇹🇷

Malatya, Turkey

Medical Center "Mriya Med-Service"

🇺🇦

Kryvyi Rih, Dnipropetrovska Oblast, Ukraine

CNPE "Regional Center of Oncology"

🇺🇦

Kharkiv, Kharkivska Oblast, Ukraine

Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council

🇺🇦

Odesa, Odeska Oblast, Ukraine

Sumy regional clinical oncological dispensary

🇺🇦

Sumy, Sumska Oblast, Ukraine

Communal Noncommercial Enterprise "Podillia Regional Oncology Center Of Vinnytsia Regional Council"

🇺🇦

Vinnytsia, Vinnytska Oblast, Ukraine

"Oncolife" LLC

🇺🇦

Zaporizhzhia, Zaporizka Oblast, Ukraine

Municipal non-profit enterprise "Kyiv City Clinical Oncology Center" of executive body of Kyiv City Counci -T

🇺🇦

Kyiv, Ukraine

Chelsea and Westminster Hospital NHS Foundation Trust

🇬🇧

London, England, United Kingdom

Royal Brompton Hospital

🇬🇧

London, Kensington And Chelsea, United Kingdom

University College London Hospital

🇬🇧

London, London, City Of, United Kingdom

City Hospital, Nottingham University Hospitals

🇬🇧

Nottingham, United Kingdom

New Cross Hospital

🇬🇧

Wolverhampton, United Kingdom

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