跳至主要内容
临床试验/NCT03882385
NCT03882385Unknown不适用

Screening For Critical Congenital Anomalies In NICU And Their Out Come in Assiut Universty

Assiut University0 个研究点目标入组 142 人开始时间: 2019年3月19日最近更新:
适应症

试验速览

阶段
不适用
入组人数
142
主要终点
detect number of total babies and percentages of congenital anomalies

研究概览

简要总结

The congenital malformation (CMF) include disturbance in normal process of organogenesis occurring before birth .

  • The (CMF) are structural ,functional, or (biochemical Molecular) defect presenting at birth.
  • The structural defect resulting from prenatal insult during period of embryogeneses.
  • The neonate with congenital malformation have differences in physiology, anatomy, in response to stress.
  • The (CMF) are important causes of infant disability , illness, deaths.
  • (CMF) classified into mild, moderate, severe and lethal

详细描述

The (CMF) may be structural abnormalities with significant effect on function (e.g) cleft palate .

Or minimal effect on clinical function but may have cosmotic impact (e.g) pre-auricular pit .

In developed countries, outcome of neonatal congenital anomalies is favourable because of availability of antenatal diagnosis, improved surgical skills and technologies, sophisticated neonatal intensive care unit, availability of total parenteral nutrition and adequate staff.

In developing countries, however, neonatal surgery is still fraught with a lot of problems including late presentation and lack of medical facilities and human resources, thereby, making newborn surgery to be associated with unacceptably high morbidity and mortality.

Due to the burden of other neonatal and childhood diseases in developing countries, neonatal surgery is often considered low priority in healthcare budget planning and allocation.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
1 Day 至 6 Months(Child)
性别
All
接受健康志愿者

入选标准

  • • Cases need resustation and stabilization.
  • Congenital anomalies that need admission in NICU eg: impeforated anus , meningiocele, heart disease, tacho osphageal fistula, urinary problems, diaphragmatic hernia, intestinal obstruction, duedodnal obstruction, neural tube defect .

排除标准

  • All vitally stable cases that don't need NICU admission and all cases not need immediate intervention of congenital anomalies

结局指标

主要结局

detect number of total babies and percentages of congenital anomalies

时间窗: 24 hours

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Amira Tharwat Helmy

principal investigator

Assiut University

相似试验