Chocolate Dynamic Vessel Analysis

Not Applicable

Completed

• Conditions: Retinal Vascular
• Interventions: Dietary Supplement: Dark chocolate; Dietary Supplement: Milk Chocolate

• Registration Number: NCT05227248
• Lead Sponsor: Querques Giuseppe

Brief Summary

The study aims at evaluating the effect of dark chocolate consumption on anatomy and functionality of retinal blood vessels by comparing these same parameters after milk chocolate consumption.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-04-09
• Primary Completion: 2021-07-13
• Study Completion: 2021-07-13
• Study First Submitted: 2022-01-26
• Study First Submitted QC: 2022-01-26
• Study First Posted: 2022-02-07
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-11
• Last Update Posted: 2025-03-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Age of 18 years or older
• Healthy volunteers
• No vascular diseases
• No ocular diseases
• Volunteers capable of understanding informed consent

Exclusion Criteria

• Patient unable to follow the instructions
• Patient unable to come back for follow-up
• opacity of lens, cornea, or vitreous
• Allergies that contraindicate pupil dilation
• Eye diseases
• Myopia greater than -8.0 Diopter (D),
• Hyperopia greater than 5.0 D
• Astigmatism greater than -3.0 D

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SEQUENTIAL

Arm && Interventions

Group	Intervention	Description
Main study arm	Milk Chocolate	Patients received intervention 1 and then intervention 2 after 7 weeks
Main study arm	Dark chocolate	Patients received intervention 1 and then intervention 2 after 7 weeks

Primary Outcome Measures

Name	Time	Method
Retinal perfusion	Baseline, 2 hours after intervention	Changes in retinal perfusion using Optical Coherence Tomography Angiography
Retinal vascular response	Baseline, 2 hours after intervention	Changes in retinal vascular response to flicker stimulation using Dynamic Vessels Analysis and Retinal Vessels Analysis

Secondary Outcome Measures

Name	Time	Method
Visual Acuity	Baseline, 2 hours after intervention	Best Corrected Visual Acuity changes

Trial Locations

Locations (1)

Giuseppe Querques; 🇮🇹 Milan, Italy