Characterization of the Sensitization Spectrum towards frequent and rare inhalation allergens in patients with severe asthma with special emphasis on regional differences

• Conditions: J45.0; J45.1; J45.8; Predominantly allergic asthma; Nonallergic asthma; Mixed asthma

• Registration Number: DRKS00011586
• Lead Sponsor: niversitätsklinik für Pneumologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-01-16
• Study Completion: 2020-10-30
• Results First Posted: 2023-05-08
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 1016

Inclusion Criteria

1. Age: 18-80 years
2. Sex: male and female
3. no restriction on body weight
4. Indication: severe asthma bronchiale (definition according to ERS = European Thoracic SocietyATS=American Thoracic Society), GINA (Global Initiative for Asthma) stages 4-5
5. Declaration of consent by signed informed consent

Exclusion Criteria

1. Chronic obstructive bronchitis (COPD)
2. Collagonia, autoimmune diseases
3. Lack of written consent or approval

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Characterization of the sensitization spectrum against frequent and rare inhalation allergens on a representative sample of 1500 patients with severe bronchial asthma

Secondary Outcome Measures

Name	Time	Method
- Differences in regional sensitization<br>- Dependence of eosinophilia on IgE-mediated sensitization<br>- Verifying the hypothesis that in patients with severe hypereosinophilic asthma, there is often no evidence of allergy