A Propensity Score-Matched Analysis of Breast-Conserving Surgery Plus Whole-Breast Irradiation Versus Mastectomy in Breast Cancer
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 9,710
- Primary Endpoint
- Cumulative incidence of ipsilateral breast tumor recurrence
Study Overview
Brief Summary
This is a retrospective propensity score-matched analysis of a large institutional cohort of patients in order to compare long-term outcomes and clinicopathologic characteristics between patients treated with breast conserving surgery or mastectomy for breast cancer.
Detailed Description
The aim of the study is to compare long-term outcomes and clinicopathologic characteristics between patients treated with breast conserving surgery + whole breast irradiation or mastectomy for breast cancer.
Recent observations regarding long-term outcomes among patients with early-stage breast cancer who underwent breast-conserving surgery plus whole-breast irradiation or mastectomy are from a small number of registry-based studies.
Therefore, these findings may overestimate differences in survival between the two groups, compared with randomized controlled trials conducted in the 1980s.
This study performed a propensity score-matched analysis in a cohort of 9710 patients aged <70 years who underwent breast conserving surgery + whole breast irradiation or mastectomy without external radiotherapy for a first primary breast cancer (pT1-2, N0-3a) at the European Institute of Oncology between 2000 and 2008.
Patients were matched by propensity score.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Retrospective
Eligibility Criteria
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •First primary breast cancer
- •Surgery performed at European Institute of Oncology between 2000 and 2008
Exclusion Criteria
- •Neoadjuvant treatment
- •Presence of metastatic breast disease at the time of admission or within 3 months
Outcomes
Primary Outcomes
Cumulative incidence of ipsilateral breast tumor recurrence
Time Frame: 10 years
Incidence of ipsilateral breast tumor recurrence in breast conserving surgery group compared to mastectomy group
Rate of distant metastasis
Time Frame: 10 years
Incidence of distant metastasis in breast conserving surgery group compared to mastectomy group
Cumulative incidence of axillary lymph node recurrence
Time Frame: 10 years
cumulative incidence of axillary lymph node recurrence in breast conserving surgery group compared to mastectomy group
Rate of overall survival
Time Frame: 10 years
Incidence of survival in breast conserving surgery group compared to mastectomy group
Cumulative incidence of contralateral breast cancer
Time Frame: 10 years
Cumulative incidence of contralateral breast cancer in breast conserving surgery group compared to mastectomy group
Cumulative incidence of breast cancer specific survival
Time Frame: 10 years
Cumulative incidence of breast cancer specific survival in breast conserving surgery group compared to mastectomy group
Secondary Outcomes
No secondary outcomes reported