A randomized, double blind, placebo-controlled study on the effect of 3 months treatment with the analgesic tapentadol on conditioned pain modulation (CPM) and pain relief in patients with chronic low back pai

Completed

• Conditions: low back pain; 10028377

• Registration Number: NL-OMON42741
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2018-10-22
• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Age: 18 - 75 years.;- Sex: Either sex.
- American Society of Anesthesiologists class 1 and 2 patients, 18 - 75 years; BMI < 40 kg/m2, and ability to give informed consent. CLBP for > 3-months with a pain score of 3 or more on a numerical rating scale.
.

Exclusion Criteria

Unable to give written informed consent; medical disease such as pulmonary, renal, liver, cardiac, gastro-intestinal, vascular disease; (iii) allergy to study medication; (iv) history of illicit drug abuse or alcohol abuse; (v) history of psychosis; (vi) epilepsy; (vii) pregnancy and/or lactation; (viii) strong opioids and benzodiazepine use; (ix) previous extensive spinal surgery or spinal surgery in the past 6 months; (x) serious spinal pathology and (xi) diagnosed neurological disease.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Pain relief and change in endogenous pain modulation</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Change in mood. daily activity and neuropathic pain cmplaints</p><br>