Standardising and Simplifying the Global Leadership Initiative on Malnutrition (GLIM) for Its More General Application
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Computed tomography (CT) defined muscle mass
研究概览
简要总结
This observational study of aims to test whether and how the results of GLIM change when using different approaches and methods to carry out its components.
详细描述
The main questions the study aims to answer are:
- What is the most effective pre-GLIM screening approach?
- Which of the simple, globally accessible muscle mass measurement methods works the best in the context of GLIM?
- How does using simpler approaches to screening and muscle mass measurement affect the performance of GLIM in detecting Subjective Global Assessment (SGA) defined malnutrition and 1-year mortality?
Participants will be/have:
- asked questions about their recent food intake and possible non-volitional weight loss
- assessed for malnutrition with SGA
- weighed, and their height will be measured (if not already recorded)
- their muscle mass measured with a measuring tape (mid-upper arm circumference and calf circumference) and bioelectrical impedance
- their muscle function measured using hand grip strength
- have their patient records looked at to extract their weight and height data (if present), diagnoses, routine blood test results, abdominal computed tomography (CT) scan (if present), dual-energy x-ray absorptiometry (DEXA) scan (if present), 1-year mortality and personal identification code for documentation (the latter will be deleted when the study period is over).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age of 18+ years
- •Able and willing to sign the consent form
- •Inpatients of the Tartu University Hospital
- •Admitted within 72 hours before enrolment
排除标准
- •Age of <18 years
- •Inability or refusal to sign the consent form
- •Pregnant or lactating women
- •More than 72 hours passed since admission
- •Patients isolating with an infection
结局指标
主要结局
Computed tomography (CT) defined muscle mass
时间窗: baseline, pre-intervention/procedure/surgery
One of the GLIM criteria is "reduced muscle mass", and this study will investigate how muscle mass measured with simpler methods compares against muscle mass measured with CT.
DEXA defined muscle mass
时间窗: baseline, pre-intervention/procedure/surgery
One of the GLIM criteria is "reduced muscle mass", and this study will investigate how muscle mass measured with simpler methods compares against muscle mass measured with DEXA.
One-year mortality
时间窗: through study completion, an average of 1 year
One year after the data collection, we will look at the patient records to collect the 1-year mortality data. This will give information about whether and how different approaches to components of GLIM affect its ability to predict one-year mortality.
Subjective Global Assessment (SGA) defined malnutrition
时间窗: baseline, pre-intervention/procedure/surgery
Subjective Global Assessment (SGA) can be considered a method that is close to a "gold standard" for malnutrition assessment. Therefore, the study will analyse how different approaches to screening and muscle mass measurement affect the performance of GLIM in detecting Subjective Global Assessment (SGA) defined malnutrition.
次要结局
- Bioelectrical impedance (BIA) defined muscle mass(baseline, pre-intervention/procedure/surgery)
研究者
Alastair Forbes
Visiting Professor
University of Tartu