Standardising and Simplifying the Global Leadership Initiative on Malnutrition (GLIM) for Its More General Application
- Conditions
- Malnutrition
- Interventions
- Diagnostic Test: Nutrition screening and assessment
- Registration Number
- NCT06164925
- Lead Sponsor
- University of Tartu
- Brief Summary
This observational study of aims to test whether and how the results of GLIM change when using different approaches and methods to carry out its components.
- Detailed Description
The main questions the study aims to answer are:
* What is the most effective pre-GLIM screening approach?
* Which of the simple, globally accessible muscle mass measurement methods works the best in the context of GLIM?
* How does using simpler approaches to screening and muscle mass measurement affect the performance of GLIM in detecting Subjective Global Assessment (SGA) defined malnutrition and 1-year mortality?
Participants will be/have:
* asked questions about their recent food intake and possible non-volitional weight loss
* assessed for malnutrition with SGA
* weighed, and their height will be measured (if not already recorded)
* their muscle mass measured with a measuring tape (mid-upper arm circumference and calf circumference) and bioelectrical impedance
* their muscle function measured using hand grip strength
* have their patient records looked at to extract their weight and height data (if present), diagnoses, routine blood test results, abdominal computed tomography (CT) scan (if present), dual-energy x-ray absorptiometry (DEXA) scan (if present), 1-year mortality and personal identification code for documentation (the latter will be deleted when the study period is over).
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 300
- Age of 18+ years
- Able and willing to sign the consent form
- Inpatients of the Tartu University Hospital
- Admitted within 72 hours before enrolment
- Age of <18 years
- Inability or refusal to sign the consent form
- Pregnant or lactating women
- More than 72 hours passed since admission
- Patients isolating with an infection
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Inpatients of the Tartu University Hospital Nutrition screening and assessment Inclusion Criteria: Age of 18+ years, able and willing to sign the consent form, inpatients of the Tartu University Hospital, admitted within 72 hours before enrolment. Exclusion Criteria: Age of \<18 years, inability or refusal to sign the consent form, pregnant or lactating women, more than 72 hours passed since admission, patients isolating with an infection.
- Primary Outcome Measures
Name Time Method Computed tomography (CT) defined muscle mass baseline, pre-intervention/procedure/surgery One of the GLIM criteria is "reduced muscle mass", and this study will investigate how muscle mass measured with simpler methods compares against muscle mass measured with CT.
DEXA defined muscle mass baseline, pre-intervention/procedure/surgery One of the GLIM criteria is "reduced muscle mass", and this study will investigate how muscle mass measured with simpler methods compares against muscle mass measured with DEXA.
One-year mortality through study completion, an average of 1 year One year after the data collection, we will look at the patient records to collect the 1-year mortality data. This will give information about whether and how different approaches to components of GLIM affect its ability to predict one-year mortality.
Subjective Global Assessment (SGA) defined malnutrition baseline, pre-intervention/procedure/surgery Subjective Global Assessment (SGA) can be considered a method that is close to a "gold standard" for malnutrition assessment. Therefore, the study will analyse how different approaches to screening and muscle mass measurement affect the performance of GLIM in detecting Subjective Global Assessment (SGA) defined malnutrition.
- Secondary Outcome Measures
Name Time Method Bioelectrical impedance (BIA) defined muscle mass baseline, pre-intervention/procedure/surgery One of the GLIM criteria is "reduced muscle mass", and this study will investigate how muscle mass measured with simpler methods compares against muscle mass measured with BIA.
Trial Locations
- Locations (1)
Tartu Ülikooli Kliinikum
🇪🇪Tartu, Tartumaa, Estonia