Evaluating the chloride levels and pH values following Sterofundin and Plasmalyte infusion in elective major abdominal surgery
Not Applicable
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2024/07/069723
- Lead Sponsor
- Postgraduate Institute of Medical Education and Research Chandigarh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients between age 18 to 70 years undergoing elective major abdominal surgery (more than 2 hours of projected operating time)
ASA-PS class 1, 2 and 3
Exclusion Criteria
Patients who are hemodynamically unstable preoperatively
Presence of preoperative metabolic acidosis (arterial pH lower than 7.2, lactate over 2 mmol per L, bicarbonate less than 16 mEq/L)
Acute and, or chronic kidney disease
Presence of preoperative fluid overload (pleural, pericardial effusion, ascites)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To estimate the difference in serum chloride and pH at the end of major abdominal surgery between the sterofundin and plasmalyte groupTimepoint: At the time of skin closure and before extubation
- Secondary Outcome Measures
Name Time Method To compare blood gas parameters (HCO3-, BE, pCO2, pO2), electrolytes (Na+, K+, Ca++, Mg++) and lactate at the end of surgery.Timepoint: At the end of surgery;To compare the difference in strong ion difference using stewarts approachTimepoint: At the time of skin closure and before extubation;To compare the prevalence of postoperative AKI as per KDIGO criteriaTimepoint: At the end of postoperative day 7;To compare the total volume of intraoperative crystalloids, colloids and blood products used.Timepoint: Intra operative period;To compare the Vasoactive Inotrope scores between the groupsTimepoint: At the end of surgery