Contribution of the Kinematic Theory in the Early Differential Diagnosis of the Parkinson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Lognormal primitives
研究概览
简要总结
The working hypotheses are as follows: #1 The processing of performance signals by automated lognormal segmentation and the extraction of the parameters of interest will make it possible to distinguish groups of patients from healthy elderly subjects. #2 The three instrumental approaches will not have the same degree of reliability as a predictive biomarker of clinical diagnosis established by consensus.
详细描述
The strength of this study is to compares three refined parametric approaches drawn from functions mediated by very different neuromuscular programs (visually guided voluntary movement control to perform trajectories with the hand or arm versus vocal control) among two groups of patients and a healthy group. Its weakness lies in the lack of multimodal methods to accurately confirm clinical diagnosis and the predictive reliability of patient performance. These modalities are too costly to be included in this project. However, different oculovisual measurement standards such as optical coherence tomography, hyperspectral imaging (OPTINA Diagnostics Inc.), and eye tracking will be used at the School of Optometry, University of Montreal. There is indeed a remodeling of the retina and oculomotor changes in Parkinson's Disease (PD) and these non-invasive techniques, which have been accepted for several years, will be used in patients in support of their clinical diagnosis compared to normal subjects.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Being diagnosed with Parkinsonism including idiopathic Parkinson's disease or a related syndrome;
- •Have motor symptoms of Parkinsonism for 6 years or less;
- •Be a healthy volunteer subject in good general health with no prior neurological history;
- •Age between 50-75 years old;
- •If applicable, be able to safely leave home in the morning without having taken antiparkinsonian medication for the past 12 hours.
排除标准
- •Major neurocognitive disorders;
- •History of other neurological conditions, such as ischemic or hemorrhagic stroke, paralysis of a limb, traumatic brain injury, epilepsy, orofacial dystonia, essential tremor;
- •History of oromandibular or laryngeal procedures;
- •Uncorrected deafness;
- •Any contraindication to pupillary dilation.
结局指标
主要结局
Lognormal primitives
时间窗: Day 1
Velocity profiles generated for simple movements (strokes) and certain vocal frequencies (formants), transformed to fit into the lognormal model
次要结局
- Optical Coherence Tomography measures(Day 1)
- Radboud Oral Motor Inventory for Parkinson's Disease(Day 1)
- Movement Disorder Society-Unified Parkinson's Disease Rating Scale section III(Day 1)