NCT00309660Unknown1 期
Treatment With Local PPARgamma Ligand in Distal Ulcerative Colitis
适应症
相关药物
试验速览
- 阶段
- 1 期
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Clinical response
研究概览
简要总结
Treatment with PPARgamma ligands have been shown to reduces intestinal inflammation in murine models of colitis. The aim of this study was to evaluate the effect of treatment with local PPARgamma ligand (rosiglitazone) in distal ulcerative colitis.The patients are treated with rosiglitazone enema, once a day, for fourteen days. Disease activity was assessed before and after treatment by endoscopical and clinical activity score.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Distal ulcerative colitis (Mayo Clinical Score > 7)
- •Age > 18 years
- •Written consent
排除标准
- •Age < 18 years
- •Severe ulcerative colitis
- •Systemic treatment with steroids or azathioprin within the last 3 month
- •Known liver or kidney disease
- •Severe heart failure
- •Pregnancy or breast feeding
结局指标
主要结局
Clinical response
次要结局
- Endoscopic response
研究者
研究点 (2)
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