Descendance Cohort: Follow-up of Subjects With Type 2 Diabetes or at Risk of Type 2 Diabetes Defined by the Existence of the Disease in the Family in Two Successive Generations
试验速览
- 阶段
- 不适用
- 状态
- 暂停
- 发起方
- 入组人数
- 837
- 试验地点
- 2
- 主要终点
- Type 2 diabetes incidence in Descendance population
研究概览
简要总结
The main objective of this study is to prospectively follow the subjects included in "Descendance" cohort and to describe the occurrence of type 2 diabetes in non-diabetic subjects, which will allow us to iteratively update the "Descendance" Type 2 Diabetes risk prediction model.
详细描述
High risk families will be prospectively follow in order to better understand the risk of transmission of type 2 diabetes from one generation to another. The cohort will also allow us to collect additional data on diabetic patients.
The monitoring of the cohort will take place for at least 10 years with a follow-up of all participants every three years. To detect individuals who develop dysglycemia during the study, a glucose tolerance test (GTT) and HbA1c measurement will be conducted.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects have participated in the Descendance study
- •Subjets who sign informed consent to participate in the study
排除标准
- •Subjects not enrolled in Descendance study
- •Subjects refusing to participate
- •Pregnant or breastfeeding
- •Subjects in emergency situations, under legal protection or unable to provide informed -consent
- •Subjects lost to follow-up or died
研究组 & 干预措施
T2D group
subjects with type 2 diabetes
干预措施: Questionnaire (Other)
Non-T2D group
healthy subjects
干预措施: OGTT (Diagnostic Test)
Non-T2D group
healthy subjects
干预措施: HbA1c (Other)
Non-T2D group
healthy subjects
干预措施: Questionnaire (Other)
结局指标
主要结局
Type 2 diabetes incidence in Descendance population
时间窗: 9years
Presence of type 2 diabetes mellitus, on basis of self-reported (physician diagnosis) or diagnosed by OGTT and HbA1c
次要结局
- Provide estimates of prevalence of diabetes and prediabetes in Descendance population(at baseline, 3-, 6- and 9-years follow-up)
- Study of interactions between risk factors on type 2 diabetes incidence(at baseline, 3-, 6- and 9-years follow-up)