The Effects of Dexmedetomidine and Tracheal Intubation on Heart Rate Variability and QTc Interval
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Change of QTc interval
研究概览
简要总结
The purpose of this study is to investigate effect of dexmedetomidine and tracheal intubation on heart rate variability and QTc interval.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient who are regarded as ASA class I
- •age 20 to 60
- •patient scheduled for Intubation for surgery
排除标准
- •QTc interval > 440 ms
- •arrythmia
- •Patient who is taking a medicine which effects QTc interval
- •renal disease
- •hepatic disease
- •illiterate
研究组 & 干预措施
Control
fentanyl 1 mcg/kg before induction
干预措施: 0.5 mcg/kg IV infusion for 10 min, 1.0 mcg/kg IV infusion for 10 min (Drug)
D 0.5 group
Dexmedetomidine 0.5 ug/kg + Propofol + Sevoflurane+ Vecuronium
干预措施: 0.5 mcg/kg IV infusion for 10 min, 1.0 mcg/kg IV infusion for 10 min (Drug)
D 1.0 group
Dexmedetomidine 1.0 ug/kg + Propofol + Sevoflurane+ Vecuronium
干预措施: 0.5 mcg/kg IV infusion for 10 min, 1.0 mcg/kg IV infusion for 10 min (Drug)
结局指标
主要结局
Change of QTc interval
时间窗: T1 (at rest), T2 (5 min after dexmedetomidine infusion), T3 (just before intubation), T4(1 min after intubation), T5(2 min after intubation), T6(3min after intubation)
T1- baseline, T2- to evaluate the effect of dexmedetomidine on QTc interval, T3- to evaluate QTc interval just before intubation, T4,5,6 - to evaluate QTc interval after intubation
次要结局
未报告次要终点